Literature DB >> 2106478

Genetic studies on human thyroxine-binding globulin (TBG).

C Luckenbach1, J Kömpf, H Ritter.   

Abstract

An enzyme immunoassay technique combined with Western blotting is described to demonstrate thyroxine-binding globulin (TBG) by isoelectric focusing in thin-layer polyacrylamide gels with 8 mol/l urea. Quantitative evaluation was by laser densitometry. No genetic charge variants of TBG were encountered in a sample of 840 unrelated individuals from southwestern Germany. There was no correlation between structural and quantitative variations in the TBG protein. Results from a family with quantitative TBG deficiency strongly support the postulated X-linked mode of inheritance. The method described can be considered as an additional diagnostic tool in thyroid evaluation.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2106478     DOI： 10.1007/bf00196237

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  9 in total

1.  Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases.

Authors:  I L Flink; T J Bailey; T A Gustafson; B E Markham; E Morkin
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

2.  Detection of genetic variation with radioactive ligands. I. Electrophoretic screening of plasma proteins with a selected panel of compounds.

Authors:  L L Cavalli-Sforza; S P Daiger; D P Rummel
Journal:  Am J Hum Genet       Date:  1977-11       Impact factor: 11.025

3.  Structure and stability of human thyroxine-binding globulin.

Authors:  M C Gershengorn; R E Lippoldt; H Edelhoch; J Robbins
Journal:  J Biol Chem       Date:  1977-12-10       Impact factor: 5.157

4.  Localization of the human thyroxine-binding globulin gene to the long arm of the X chromosome (Xq21-22).

Authors:  J M Trent; I L Flink; E Morkin; P van Tuinen; D H Ledbetter
Journal:  Am J Hum Genet       Date:  1987-09       Impact factor: 11.025

5.  Preparation of glycopeptides and oligosaccharides from thyroxine-binding globulin.

Authors:  A B Zinn; J S Marshall; D M Carlson
Journal:  J Biol Chem       Date:  1978-10-10       Impact factor: 5.157

6.  Genetic polymorphism of thyroxin-binding globulin (TBG) in the Pacific area.

Authors:  M I Kamboh; C Kirwood
Journal:  Am J Hum Genet       Date:  1984-05       Impact factor: 11.025

7.  Study of four new kindreds with inherited thyroxine-binding globulin abnormalities. Possible mutations of a single gene locus.

Authors:  S Refetoff; N I Robin; C A Alper
Journal:  J Clin Invest       Date:  1972-04       Impact factor: 14.808

8.  [Familial coincidence of hypertrophic cardiomyopathies and thyroxine-binding globulin deficiency (athyropexinemia) (author's transl)].

Authors:  E Kallee; J Bohner; H Eichstädt; R Haasis; R Wahl; K Kochsiek
Journal:  Klin Wochenschr       Date:  1978-12-15

9.  Distribution and inheritance of low serum thyroxine-binding globulin levels in Australian Aborigines: a new genetic variation.

Authors:  F Watson; M Dick
Journal:  Med J Aust       Date:  1980-10-04       Impact factor: 7.738
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.