BACKGROUND: Overall survival in paediatric cancer has improved significantly over the past 20 years. Treatment strategies have been intensified, and supportive care has made substantial advances. Historically, paediatric oncology patients admitted to an intensive care unit (ICU) have had extremely poor outcomes. METHODS: We conducted a retrospective cohort study over a 3-year period in a single centre to evaluate the outcomes for this particularly vulnerable group of patients admitted to a paediatric ICU. RESULTS: Fifty-five patients were admitted a total of 66 times to the ICU during the study period. The mortality rate of this group was 23% compared with an overall ICU mortality rate of 5%. 11/15 patients who died had an underlying haematological malignancy. Twenty-eight percent of children with organism-identified sepsis died. CONCLUSIONS: While mortality rates for paediatric oncology patients admitted to a ICU have improved, they are still substantial. Those with a haematological malignancy or admitted with sepsis are most at risk.
BACKGROUND: Overall survival in paediatric cancer has improved significantly over the past 20 years. Treatment strategies have been intensified, and supportive care has made substantial advances. Historically, paediatric oncology patients admitted to an intensive care unit (ICU) have had extremely poor outcomes. METHODS: We conducted a retrospective cohort study over a 3-year period in a single centre to evaluate the outcomes for this particularly vulnerable group of patients admitted to a paediatric ICU. RESULTS: Fifty-five patients were admitted a total of 66 times to the ICU during the study period. The mortality rate of this group was 23% compared with an overall ICU mortality rate of 5%. 11/15 patients who died had an underlying haematological malignancy. Twenty-eight percent of children with organism-identified sepsis died. CONCLUSIONS: While mortality rates for paediatric oncology patients admitted to a ICU have improved, they are still substantial. Those with a haematological malignancy or admitted with sepsis are most at risk.
Authors: A van Veen; A Karstens; A C van der Hoek; D Tibboel; K Hählen; E van der Voort Journal: Intensive Care Med Date: 1996-03 Impact factor: 17.440
Authors: Ephraim L Tsalik; Daphne Jones; Bradly Nicholson; Lynette Waring; Oliver Liesenfeld; Lawrence P Park; Seth W Glickman; Lauren B Caram; Raymond J Langley; Jennifer C van Velkinburgh; Charles B Cairns; Emanuel P Rivers; Ronny M Otero; Stephen F Kingsmore; Tahaniyat Lalani; Vance G Fowler; Christopher W Woods Journal: J Clin Microbiol Date: 2009-10-21 Impact factor: 5.948
Authors: A Reiter; M Schrappe; W D Ludwig; W Hiddemann; S Sauter; G Henze; M Zimmermann; F Lampert; W Havers; D Niethammer Journal: Blood Date: 1994-11-01 Impact factor: 22.113
Authors: Richard F Louie; Zuping Tang; Timothy E Albertson; Stuart Cohen; Nam K Tran; Gerald J Kost Journal: Crit Care Med Date: 2008-05 Impact factor: 7.598
Authors: Matt S Zinter; Steven G DuBois; Aaron Spicer; Katherine Matthay; Anil Sapru Journal: Intensive Care Med Date: 2014-07-15 Impact factor: 17.440
Authors: Shannon L Maude; Julie C Fitzgerald; Brian T Fisher; Yimei Li; Yuan-Shung Huang; Kari Torp; Alix E Seif; Marko Kavcic; Dana M Walker; Kateri H Leckerman; Todd J Kilbaugh; Susan R Rheingold; Lillian Sung; Theoklis E Zaoutis; Robert A Berg; Vinay M Nadkarni; Neal J Thomas; Richard Aplenc Journal: Pediatr Crit Care Med Date: 2014-02 Impact factor: 3.624
Authors: Pierre Demaret; Geraldine Pettersen; Philippe Hubert; Pierre Teira; Guillaume Emeriaud Journal: Ann Intensive Care Date: 2012-06-12 Impact factor: 6.925