Literature DB >> 21063502

CCN5: biology and pathophysiology.

Joshua W Russo, John J Castellot.   

Abstract

CCN5 is one of six proteins in the CCN family. This family of proteins has been shown to play important roles in many processes, including proliferation, migration, adhesion, extracellular matrix regulation, angiogenesis, tumorigenesis, fibrosis, and implantation. In this review, we focus on the biological and putative pathophysiological roles of CCN5. This intriguing protein is structurally unique among the CCN family members, and has a unique biological activity profile as well.

Entities:  

Keywords:  CCN proteins; Matricellular; Nuclear localization; Review

Year:  2010        PMID： 21063502      PMCID： PMC2948116          DOI： 10.1007/s12079-010-0098-7

Source DB:  PubMed          Journal:  J Cell Commun Signal        ISSN： 1873-9601            Impact factor:   5.782


  46 in total

1.  Peptides derived from type I thrombospondin repeat-containing proteins of the CCN family inhibit proliferation and migration of endothelial cells.

Authors:  Emmanouil D Karagiannis; Aleksander S Popel
Journal:  Int J Biochem Cell Biol       Date:  2007-07-30       Impact factor: 5.085

2.  WISP-2/CCN5 is involved as a novel signaling intermediate in phorbol ester-protein kinase Calpha-mediated breast tumor cell proliferation.

Authors:  Krishanu Sengupta; Snigdha Banerjee; Kakali Dhar; Neela K Saxena; Smita Mehta; Donald R Campbell; Sushanta K Banerjee
Journal:  Biochemistry       Date:  2006-09-05       Impact factor: 3.162

3.  WISP-2: a serum-inducible gene differentially expressed in human normal breast epithelial cells and in MCF-7 breast tumor cells.

Authors:  M N Zoubine; S Banerjee; N K Saxena; D R Campbell; S K Banerjee
Journal:  Biochem Biophys Res Commun       Date:  2001-03-30       Impact factor: 3.575

4.  Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions.

Authors:  S Kumar; A T Hand; J R Connor; R A Dodds; P J Ryan; J J Trill; S M Fisher; M E Nuttall; D B Lipshutz; C Zou; S M Hwang; B J Votta; I E James; D J Rieman; M Gowen; J C Lee
Journal:  J Biol Chem       Date:  1999-06-11       Impact factor: 5.157

5.  Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection.

Authors:  Olga Aprelikova; Matthew Wood; Sean Tackett; Gadisetti V R Chandramouli; J Carl Barrett
Journal:  Cancer Res       Date:  2006-06-01       Impact factor: 12.701

6.  Expression and regulation of CCN genes in murine osteoblasts.

Authors:  Muriel S Parisi; Elizabetta Gazzerro; Sheila Rydziel; Ernesto Canalis
Journal:  Bone       Date:  2005-11-28       Impact factor: 4.398

7.  Expression and regulation of WISP2 in rheumatoid arthritic synovium.

Authors:  Ichiro Tanaka; Masako Morikawa; Toshiyuki Okuse; Masayori Shirakawa; Kazushi Imai
Journal:  Biochem Biophys Res Commun       Date:  2005-09-09       Impact factor: 3.575

8.  PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3beta in osteoblastic Saos-2 cells.

Authors:  Akira Suzuki; Keiichi Ozono; Takuo Kubota; Hiroki Kondou; Kanako Tachikawa; Toshimi Michigami
Journal:  J Cell Biochem       Date:  2008-05-01       Impact factor: 4.429

9.  CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells.

Authors:  Snigdha Banerjee; Gopal Dhar; Inamul Haque; Suman Kambhampati; Smita Mehta; Krishanu Sengupta; Ossama Tawfik; Teresa A Phillips; Sushanta K Banerjee
Journal:  Cancer Res       Date:  2008-09-15       Impact factor: 12.701

Review 10.  Functions and mechanisms of action of CCN matricellular proteins.

Authors:  Chih-Chiun Chen; Lester F Lau
Journal:  Int J Biochem Cell Biol       Date:  2008-08-15       Impact factor: 5.085
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  28 in total

Review 1.  Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets.

Authors:  Joon-Il Jun; Lester F Lau
Journal:  Nat Rev Drug Discov       Date:  2011-12-01       Impact factor: 84.694

Review 2.  Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization.

Authors:  Andrew J Sawyer; Themis R Kyriakides
Journal:  Adv Drug Deliv Rev       Date:  2016-01-04       Impact factor: 15.470

Review 3.  The role of the CCN family of proteins in female reproduction.

Authors:  Elke Winterhager; Alexandra Gellhaus
Journal:  Cell Mol Life Sci       Date:  2014-01-22       Impact factor: 9.261

4.  CCN5/WISP-2 promotes growth arrest of triple-negative breast cancer cells through accumulation and trafficking of p27(Kip1) via Skp2 and FOXO3a regulation.

Authors:  I Haque; S Banerjee; A De; G Maity; S Sarkar; M Majumdar; S S Jha; D McGragor; S K Banerjee
Journal:  Oncogene       Date:  2014-08-18       Impact factor: 9.867

5.  The role of CCN family genes in haematological malignancies.

Authors:  J E Wells; M Howlett; L C Cheung; Ursula R Kees
Journal:  J Cell Commun Signal       Date:  2015-05-31       Impact factor: 5.782

6.  Loss of Wasl improves pancreatic cancer outcome.

Authors:  Ana Hidalgo-Sastre; Judit Desztics; Zahra Dantes; Katharina Schulte; Hilal Kabadayi Ensarioglu; Blessing Bassey-Archibong; Rupert Öllinger; Thomas Engleiter; Lyndsay Rayner; Henrik Einwächter; Juliet M Daniel; Ali Sameer Abdulghani Altaee; Katia Steiger; Marina Lesina; Roland Rad; Maximilian Reichert; Guido von Figura; Jens T Siveke; Roland M Schmid; Clara Lubeseder-Martellato
Journal:  JCI Insight       Date:  2020-05-21

7.  CCN5/WISP-2: A micromanager of breast cancer progression.

Authors:  Sushanta K Banerjee; Snigdha Banerjee
Journal:  J Cell Commun Signal       Date:  2012-04-10       Impact factor: 5.782

8.  Cysteine-rich 61-connective tissue growth factor-nephroblastoma-overexpressed 5 (CCN5)/Wnt-1-induced signaling protein-2 (WISP-2) regulates microRNA-10b via hypoxia-inducible factor-1α-TWIST signaling networks in human breast cancer cells.

Authors:  Inamul Haque; Snigdha Banerjee; Smita Mehta; Archana De; Monami Majumder; Matthew S Mayo; Suman Kambhampati; Donald R Campbell; Sushanta K Banerjee
Journal:  J Biol Chem       Date:  2011-10-21       Impact factor: 5.157

9.  Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile.

Authors:  Cristina Oliveras-Ferraros; Alejandro Vazquez-Martin; Elisabet Cuyàs; Bruna Corominas-Faja; Esther Rodríguez-Gallego; Salvador Fernández-Arroyo; Begoña Martin-Castillo; Jorge Joven; Javier A Menendez
Journal:  Cell Cycle       Date:  2014-02-07       Impact factor: 4.534

10.  Human pancreatic cancer progression: an anarchy among CCN-siblings.

Authors:  Sushanta K Banerjee; Gargi Maity; Inamul Haque; Arnab Ghosh; Sandipto Sarkar; Vijayalaxmi Gupta; Donald R Campbell; Daniel Von Hoff; Snigdha Banerjee
Journal:  J Cell Commun Signal       Date:  2016-08-19       Impact factor: 5.782
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