Literature DB >> 2106318

Determination of amyloid beta protein precursors harboring active form of proteinase inhibitor domains in cerebrospinal fluid of Alzheimer's disease patients by trypsin-antibody sandwich ELISA.

N Kitaguchi1, Y Tokushima, K Oishi, Y Takahashi, S Shiojiri, S Nakamura, S Tanaka, R Kodaira, H Ito.   

Abstract

beta-Amyloid protein precursors (APP) having proteinase inhibitor domains (APPI) were quantified by a new sandwich enzyme linked immunosorbent assay for detection of active (free) form of proteinase inhibitors by using trypsin in place of the first antibody and by denaturation of APPI-trypsin complex in the microtiterplate. The concentration of APPs having APPI in cerebrospinal fluid of Alzheimer's disease patients was found, by this method, to be significantly elevated compared with those of multi-infarct dementia.

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Year:  1990        PMID： 2106318     DOI： 10.1016/0006-291x(90)91030-v

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Immunohistochemical localization of the proteinase inhibitor region of amyloid precursor proteins in the neocortex of Alzheimer's disease and aged controls.

Authors:  S Nakamura; T Suenaga; I Akiguchi; J Kimura; S Nakamura; Y Tokushima; N Kitaguchi; Y Takahashi; S Shiojiri
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088

Review 2.  The role of beta-amyloid in the development of Alzheimer's disease.

Authors:  K Ii
Journal:  Drugs Aging       Date:  1995-08       Impact factor: 3.923

Review 3.  The role of beta-amyloid peptide in Alzheimer's disease.

Authors:  A LeBlanc
Journal:  Metab Brain Dis       Date:  1994-03       Impact factor: 3.584

4.  Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients.

Authors:  W E Van Nostrand; S L Wagner; W R Shankle; J S Farrow; M Dick; J M Rozemuller; M A Kuiper; E C Wolters; J Zimmerman; C W Cotman
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-01       Impact factor: 11.205

5.  Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease.

Authors:  K Nishiyama; B D Trapp; T Ikezu; R M Ransohoff; T Tomita; T Iwatsubo; I Kanazawa; K K Hsiao; M P Lisanti; T Okamoto
Journal:  J Neurosci       Date:  1999-08-01       Impact factor: 6.167

Review 6.  Multifunctional roles of enolase in Alzheimer's disease brain: beyond altered glucose metabolism.

Authors:  D Allan Butterfield; Miranda L Bader Lange
Journal:  J Neurochem       Date:  2009-09-23       Impact factor: 5.372

Review 7.  Biomarkers of Alzheimer's disease.

Authors:  Rebecca Craig-Schapiro; Anne M Fagan; David M Holtzman
Journal:  Neurobiol Dis       Date:  2008-10-28       Impact factor: 5.996

8.  Amino acid sequence RERMS represents the active domain of amyloid beta/A4 protein precursor that promotes fibroblast growth.

Authors:  H Ninomiya; J M Roch; M P Sundsmo; D A Otero; T Saitoh
Journal:  J Cell Biol       Date:  1993-05       Impact factor: 10.539

9.  Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments.

Authors:  Marianne K O Grant; Maureen Handoko; Malgorzata Rozga; Gunnar Brinkmalm; Erik Portelius; Kaj Blennow; Karen H Ashe; Kathleen R Zahs; Peng Liu
Journal:  PLoS One       Date:  2019-02-28       Impact factor: 3.240
  9 in total

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