BACKGROUND AND OBJECTIVE: Delayed recovery of platelets can be found in recipients of related donor haploidentical haematopoietic stem cell transplantation (HSCT). The objective of this study was to evaluate the safety of recombinant human thrombopoietin (rhTPO) administration prior to engraftment in patients who received related donor haploidentical HSCT. METHODS: Nineteen patients with haematological malignancies received rhTPO prior to platelet engraftment after related donor haploidentical HSCT. Safety and tolerability levels together with the influence of rhTPO on the outcome of transplantation were evaluated. RESULTS: Slight elevations in ALT and/or AST were observed in five patients; in two other patients, bilirubin levels increased slightly. No significant changes in routine examination findings and no allergic reactions were observed during the study period. Eighteen patients achieved platelet engraftment at a median of 16 (range 11-34) days. The cumulative ± SD incidence of acute graft-versus-host disease (GVHD) grade 1-4 at +100 days was 68.4 ± 10.7%, and that of chronic GVHD at 3 years was 24.7 ± 10.7%. Nine (47.4%) patients survived free of relapse, with a median follow-up of 1631 (1550-1734) days after transplantation. CONCLUSION: Early administration of rhTPO prior to engraftment was safe and well tolerated in patients receiving related donor haploidentical HSCT.
BACKGROUND AND OBJECTIVE: Delayed recovery of platelets can be found in recipients of related donor haploidentical haematopoietic stem cell transplantation (HSCT). The objective of this study was to evaluate the safety of recombinant humanthrombopoietin (rhTPO) administration prior to engraftment in patients who received related donor haploidentical HSCT. METHODS: Nineteen patients with haematological malignancies received rhTPO prior to platelet engraftment after related donor haploidentical HSCT. Safety and tolerability levels together with the influence of rhTPO on the outcome of transplantation were evaluated. RESULTS: Slight elevations in ALT and/or AST were observed in five patients; in two other patients, bilirubin levels increased slightly. No significant changes in routine examination findings and no allergic reactions were observed during the study period. Eighteen patients achieved platelet engraftment at a median of 16 (range 11-34) days. The cumulative ± SD incidence of acute graft-versus-host disease (GVHD) grade 1-4 at +100 days was 68.4 ± 10.7%, and that of chronic GVHD at 3 years was 24.7 ± 10.7%. Nine (47.4%) patients survived free of relapse, with a median follow-up of 1631 (1550-1734) days after transplantation. CONCLUSION: Early administration of rhTPO prior to engraftment was safe and well tolerated in patients receiving related donor haploidentical HSCT.
Authors: S N Wolff; R Herzig; J Lynch; S G Ericson; J P Greer; R Stein; S Goodman; M C Benyunes; M Ashby; D V Jones; J Fay Journal: Bone Marrow Transplant Date: 2001-02 Impact factor: 5.483
Authors: S N Rabinowe; R J Soiffer; N J Tarbell; D Neuberg; A S Freedman; J Seifter; K W Blake; J G Gribben; K C Anderson; T Takvorian Journal: Blood Date: 1991-04-15 Impact factor: 22.113
Authors: R A Nash; R Kurzrock; J DiPersio; J Vose; C Linker; D Maharaj; A P Nademanee; R Negrin; S Nimer; H Shulman; M Ashby; D Jones; F R Appelbaum; R Champlin Journal: Biol Blood Marrow Transplant Date: 2000 Impact factor: 5.742
Authors: M Fanucchi; J Glaspy; J Crawford; J Garst; R Figlin; W Sheridan; D Menchaca; D Tomita; H Ozer; L Harker Journal: N Engl J Med Date: 1997-02-06 Impact factor: 91.245
Authors: T R Ulich; J del Castillo; S Yin; S Swift; D Padilla; G Senaldi; L Bennett; J Shutter; J Bogenberger; D Sun Journal: Blood Date: 1995-08-01 Impact factor: 22.113
Authors: L Gao; Y Li; Y Zhang; X Chen; L Gao; C Zhang; Y Liu; P Kong; Q Wang; Y Su; C Wang; S Wang; B Li; A Sun; X Du; D Zeng; J Li; H Liu; X Zhang Journal: Bone Marrow Transplant Date: 2014-01-27 Impact factor: 5.483