| Literature DB >> 21062039 |
Huihui Fang1, Xiaoyu Wu, Linlin Nie, Xiaoyang Dai, Jie Chen, Weiguo Cao, Gang Zhao.
Abstract
An expedient diastereoselective synthesis of highly functionalized indolo[2,3-α]quinolizidines adopting a cis H2/H12b geometry has been realized by a Pictet-Spengler/lactamization cascade sequence. The absolute stereochemistry at C2, C3, and C12b was governed by the originally created chirality of the Michael adduct through organocatalyzed conjugate addition of dialkyl malonates to α,β-unsaturated aldehydes.Entities:
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Year: 2010 PMID： 21062039 DOI： 10.1021/ol101922h
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005