| Literature DB >> 2106141 |
S L Asa1, K Kovacs, L Stefaneanu, E Horvath, N Billestrup, C Gonzalez-Manchon, W Vale.
Abstract
It has been shown that mice transgenic for human growth hormone-releasing hormone (GRH) develop hyperplasia of pituitary somatotrophs and mammosomatotrophs, cells capable of producing both growth hormone and prolactin, by 8 months of age. We now report for the first time that old GRH-transgenic mice, 16 to 24 months of age, develop pituitary mammosomatotroph adenomas. These findings provide conclusive evidence that protracted stimulation of secretory activity can cause proliferation, hyperplasia and adenoma of adenohypophysial cells.Entities:
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Year: 1990 PMID： 2106141 DOI： 10.3181/00379727-193-3-rc1
Source DB: PubMed Journal: Proc Soc Exp Biol Med ISSN： 0037-9727