Literature DB >> 21061146

Effects of low molecular weight sulfated galactan fragments from Botryocladia occidentalis on the pharmacological and enzymatic activity of sPLA2 from Crotalus durissus cascavella.

M H Toyama1, D O Toyama, V M Torres, G C Pontes, W R L Farias, F R Melo, S C B Oliveira, F H R Fagundes, E B S Diz Filho, B S Cavada.   

Abstract

Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2.

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Year:  2010        PMID： 21061146     DOI： 10.1007/s10930-010-9294-9

Source DB:  PubMed          Journal:  Protein J        ISSN： 1572-3887            Impact factor:   2.371


  24 in total

1.  The isolated chick biventer cervicis nerve-muscle preparation.

Authors:  B L GINSBORG; J WARRINER
Journal:  Br J Pharmacol Chemother       Date:  1960-09

2.  Biological and structural characterization of a new PLA2 from the Crotalus durissus collilineatus venom.

Authors:  M H Toyama; D O Toyama; Paulo P Joazeiro; E M Carneiro; L O S Beriam; L S Marangoni; A C Boschero
Journal:  Protein J       Date:  2005-02       Impact factor: 2.371

3.  Human neutrophil migration in vitro induced by secretory phospholipases A2: a role for cell surface glycosaminoglycans.

Authors:  Alessandra Gambero; Elen C T Landucci; Marcos H Toyama; Sergio Marangoni; Jose R Giglio; Helena B Nader; Carl P Dietrich; Gilberto De Nucci; Edson Antunes
Journal:  Biochem Pharmacol       Date:  2002-01-01       Impact factor: 5.858

4.  Effects of morin on snake venom phospholipase A2 (PLA2).

Authors:  Carolina Veras Iglesias; Ricardo Aparicio; Léa Rodrigues-Simioni; Enilton A Camargo; Edson Antunes; Sergio Marangoni; Daniela de Oliveira Toyama; Luis O S Beriam; Helena Serra Azul Monteiro; Marcos H Toyama
Journal:  Toxicon       Date:  2005-09-23       Impact factor: 3.033

Review 5.  Sulfated polysaccharides extracted from sea algae as potential antiviral drugs.

Authors:  M Witvrouw; E De Clercq
Journal:  Gen Pharmacol       Date:  1997-10

6.  Amino acid sequence of piratoxin-II, a myotoxic lys49 phospholipase A(2) homologue from Bothrops pirajai venom.

Authors:  M H Toyama; A M Soares; L Wen-Hwa; I Polikarpov; J R Giglio; S Marangoni
Journal:  Biochimie       Date:  2000-03       Impact factor: 4.079

7.  Inflammatory oedema induced by phospholipases A2 isolated from Crotalus durissus sp. in the rat dorsal skin: a role for mast cells and sensory C-fibers.

Authors:  Paula R S Câmara; Laura C M Esquisatto; Enilton A Camargo; Maria Teresa C P Ribela; Marcos H Toyama; Sergio Marangoni; Gilberto De Nucci; Edson Antunes
Journal:  Toxicon       Date:  2003-06       Impact factor: 3.033

8.  Structural, enzymatic and biological properties of new PLA(2) isoform from Crotalus durissus terrificus venom.

Authors:  Marcos Hikari Toyama; Daniela Garcia de Oliveira; Luis O S Beriam; José Camillo Novello; Léa Rodrigues-Simioni; Sergio Marangoni
Journal:  Toxicon       Date:  2003-06       Impact factor: 3.033

9.  Ability of fucoidan to prevent muscle necrosis induced by snake venom myotoxins: comparison of high- and low-molecular weight fractions.

Authors:  Karol Azofeifa; Yamileth Angulo; Bruno Lomonte
Journal:  Toxicon       Date:  2007-10-23       Impact factor: 3.033

10.  Modulation of the pharmacological effects of enzymatically-active PLA2 by BTL-2, an isolectin isolated from the Bryothamnion triquetrum red alga.

Authors:  Simone Cb Oliveira; Fabiana V Fonseca; Edson Antunes; Enilton A Camargo; Rafael P Morganti; Ricardo Aparício; Daniela O Toyama; Luís Os Beriam; Eudismar V Nunes; Benildo S Cavada; Celso S Nagano; Alexandre H Sampaio; Kyria S Nascimento; Marcos H Toyama
Journal:  BMC Biochem       Date:  2008-06-06       Impact factor: 4.059
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  3 in total

Review 1.  Chemical structures and bioactivities of sulfated polysaccharides from marine algae.

Authors:  Guangling Jiao; Guangli Yu; Junzeng Zhang; H Stephen Ewart
Journal:  Mar Drugs       Date:  2011-02-08       Impact factor: 6.085

Review 2.  Marine polysaccharides from algae with potential biomedical applications.

Authors:  Maria Filomena de Jesus Raposo; Alcina Maria Bernardo de Morais; Rui Manuel Santos Costa de Morais
Journal:  Mar Drugs       Date:  2015-05-15       Impact factor: 5.118

Review 3.  Perspective on the Therapeutics of Anti-Snake Venom.

Authors:  Isabel Gómez-Betancur; Vedanjali Gogineni; Andrea Salazar-Ospina; Francisco León
Journal:  Molecules       Date:  2019-09-09       Impact factor: 4.411
  3 in total

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