Literature DB >> 21061090

Centrally administered urocortin 3 inhibits food intake and gastric emptying in mice.

Miharu Ushikai1, Akihiro Asakawa, Takeo Sakoguchi, Chie Tanaka, Akio Inui.   

Abstract

Urocortin 3 (Ucn3) is recognized as a member of the corticotropin-releasing factor (CRF) family, which plays an important role in regulating food intake. We investigated the effects of centrally administered Ucn3 on food intake and gastric emptying in mice. Intracerebroventricular (ICV)administration of Ucn3 (0.1–1 nmol per mouse) decreased food intake in a dose-dependent manner. The inhibitory effect of Ucn3 on food intake was less potent than that of centrally administered CRF and Urocortin 1. ICV administration of Ucn3 (0.1–1 nmol per mouse) decreased the gastric emptying rate in a dose-dependent manner. Ucn3 decreased food intake in high-fat diet-fed obese mice as well as in lean mice. These results indicated that Ucn3 influences feeding behavior and gut motility, and may be a promising therapeutic target in the treatment of eating and functional gastrointestinal disorders.

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Year:  2011        PMID： 21061090     DOI： 10.1007/s12020-010-9420-7

Source DB:  PubMed          Journal:  Endocrine        ISSN： 1355-008X            Impact factor:   3.633


  33 in total

1.  Urocortin III-immunoreactive projections in rat brain: partial overlap with sites of type 2 corticotrophin-releasing factor receptor expression.

Authors:  Chien Li; Joan Vaughan; Paul E Sawchenko; Wylie W Vale
Journal:  J Neurosci       Date:  2002-02-01       Impact factor: 6.167

2.  Expression cloning of a human corticotropin-releasing-factor receptor.

Authors:  R Chen; K A Lewis; M H Perrin; W W Vale
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-01       Impact factor: 11.205

3.  Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.

Authors:  K Lewis; C Li; M H Perrin; A Blount; K Kunitake; C Donaldson; J Vaughan; T M Reyes; J Gulyas; W Fischer; L Bilezikjian; J Rivier; P E Sawchenko; W W Vale
Journal:  Proc Natl Acad Sci U S A       Date:  2001-06-19       Impact factor: 11.205

4.  Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats.

Authors:  Chih-Yen Chen; Akio Inui; Akihiro Asakawa; Kazunori Fujino; Ikuo Kato; Chih-Chuan Chen; Naohiko Ueno; Mineko Fujimiya
Journal:  Gastroenterology       Date:  2005-07       Impact factor: 22.682

5.  Peripheral urocortin delays gastric emptying: role of CRF receptor 2.

Authors:  T Nozu; V Martinez; J Rivier; Y Taché
Journal:  Am J Physiol       Date:  1999-04

6.  Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors.

Authors:  T M Reyes; K Lewis; M H Perrin; K S Kunitake; J Vaughan; C A Arias; J B Hogenesch; J Gulyas; J Rivier; W W Vale; P E Sawchenko
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-27       Impact factor: 11.205

7.  Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat.

Authors:  Koki Inoue; Glenn R Valdez; Teresa M Reyes; Lindsay E Reinhardt; Antoine Tabarin; Jean Rivier; Wylie W Vale; Paul E Sawchenko; George F Koob; Eric P Zorrilla
Journal:  J Pharmacol Exp Ther       Date:  2003-04       Impact factor: 4.030

8.  Effects of TSH, TRH, LH and LHRH on thermoregulation and food and water intake in the rat.

Authors:  M T Lin; P C Chu; S Y Leu
Journal:  Neuroendocrinology       Date:  1983-09       Impact factor: 4.914

9.  Comparison of the anorexigenic activity of CRF family peptides.

Authors:  Chie Tanaka; Akihiro Asakawa; Miharu Ushikai; Takeo Sakoguchi; Haruka Amitani; Mutsumi Terashi; KaiChun Cheng; Huhe Chaolu; Norifumi Nakamura; Akio Inui
Journal:  Biochem Biophys Res Commun       Date:  2009-10-20       Impact factor: 3.575

10.  Central urocortin 3 administration decreases limited-access ethanol intake in nondependent mice.

Authors:  Amanda L Sharpe; Tamara J Phillips
Journal:  Behav Pharmacol       Date:  2009-07       Impact factor: 2.293
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  6 in total

Review 1.  Brain and Gut CRF Signaling: Biological Actions and Role in the Gastrointestinal Tract.

Authors:  Yvette Tache; Muriel Larauche; Pu-Qing Yuan; Mulugeta Million
Journal:  Curr Mol Pharmacol       Date:  2018       Impact factor: 3.339

2.  The cytokine ciliary neurotrophic factor (CNTF) activates hypothalamic urocortin-expressing neurons both in vitro and in vivo.

Authors:  Matthew J Purser; Prasad S Dalvi; Zi C Wang; Denise D Belsham
Journal:  PLoS One       Date:  2013-04-23       Impact factor: 3.240

Review 3.  Controversies about a common etiology for eating and mood disorders.

Authors:  Clara Rossetti; Olivier Halfon; Benjamin Boutrel
Journal:  Front Psychol       Date:  2014-10-27

4.  The role of leptin in the control of insulin-glucose axis.

Authors:  Marie Amitani; Akihiro Asakawa; Haruka Amitani; Akio Inui
Journal:  Front Neurosci       Date:  2013-04-08       Impact factor: 4.677

5.  Centrally administered urocortin 2 decreases gorging on high-fat diet in both diet-induced obesity-prone and -resistant rats.

Authors:  P Cottone; V Sabino; T R Nagy; D V Coscina; B E Levin; E P Zorrilla
Journal:  Int J Obes (Lond)       Date:  2013-03-12       Impact factor: 5.095

6.  Intracerebroventricular urocortin 3 counteracts central acyl ghrelin-induced hyperphagic and gastroprokinetic effects via CRF receptor 2 in rats.

Authors:  Chun Yeh; Ching-Heng Ting; Ming-Luen Doong; Chin-Wen Chi; Shou-Dong Lee; Chih-Yen Chen
Journal:  Drug Des Devel Ther       Date:  2016-10-03       Impact factor: 4.162
  6 in total

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