BACKGROUND: In Parkinson's disease (PD) cell loss in the substantia nigra is known to result in motor symptoms; however widespread pathological changes occur and may be associated with non-motor symptoms such as cognitive impairment. Diffusion tensor imaging is a quantitative imaging method sensitive to the micro-structure of white matter tracts. OBJECTIVE: To measure fractional anisotropy (FA) and mean diffusivity (MD) values in the corpus callosum and cingulum pathways, defined by diffusion tensor tractography, in patients with PD, PD with dementia (PDD) and controls and to determine if these measures correlate with Mini-Mental Status Examination (MMSE) scores in parkinsonian patients. METHODS: Patients with PD (17 Males [M], 12 Females [F]), mild PDD (5 M, 1 F) and controls (8 M, 7 F) underwent cognitive testing and MRI scans. The corpus callosum was divided into four regions and the cingulum into two regions bilaterally to define tracts using the program DTIstudio (Johns Hopkins University) using the fiber assignment by continuous tracking algorithm. Volumetric MRI scans were used to measure white and gray matter volumes. RESULTS: Groups did not differ in age or education. There were no overall FA or MD differences between groups in either the corpus callosum or cingulum pathways. In PD subjects the MMSE score correlated with MD within the corpus callosum. These findings were independent of age, sex and total white matter volume. CONCLUSIONS: The data suggest that the corpus callosum or its cortical connections are associated with cognitive impairment in PD patients.
BACKGROUND: In Parkinson's disease (PD) cell loss in the substantia nigra is known to result in motor symptoms; however widespread pathological changes occur and may be associated with non-motor symptoms such as cognitive impairment. Diffusion tensor imaging is a quantitative imaging method sensitive to the micro-structure of white matter tracts. OBJECTIVE: To measure fractional anisotropy (FA) and mean diffusivity (MD) values in the corpus callosum and cingulum pathways, defined by diffusion tensor tractography, in patients with PD, PD with dementia (PDD) and controls and to determine if these measures correlate with Mini-Mental Status Examination (MMSE) scores in parkinsonianpatients. METHODS:Patients with PD (17 Males [M], 12 Females [F]), mild PDD (5 M, 1 F) and controls (8 M, 7 F) underwent cognitive testing and MRI scans. The corpus callosum was divided into four regions and the cingulum into two regions bilaterally to define tracts using the program DTIstudio (Johns Hopkins University) using the fiber assignment by continuous tracking algorithm. Volumetric MRI scans were used to measure white and gray matter volumes. RESULTS: Groups did not differ in age or education. There were no overall FA or MD differences between groups in either the corpus callosum or cingulum pathways. In PD subjects the MMSE score correlated with MD within the corpus callosum. These findings were independent of age, sex and total white matter volume. CONCLUSIONS: The data suggest that the corpus callosum or its cortical connections are associated with cognitive impairment in PDpatients.
Authors: Jin Ho Jung; Yae Ji Kim; Seok Jong Chung; Han Soo Yoo; Yang Hyun Lee; Kyoungwon Baik; Seong Ho Jeong; Young Gun Lee; Hye Sun Lee; Byoung Seok Ye; Young H Sohn; Yong Jeong; Phil Hyu Lee Journal: J Neurol Date: 2021-11-11 Impact factor: 6.682
Authors: Rodrigo D Perea; Rebecca C Rada; Jessica Wilson; Eric D Vidoni1; Jill K Morris; Kelly E Lyons; Rajesh Pahwa; Jeffrey M Burns; Robyn A Honea Journal: J Alzheimers Dis Parkinsonism Date: 2013-08-26
Authors: Rong Zhao; Tianzhong Wang; Zhengli Di; Junle Yang; Min Xu; Zhiqin Liu; Xurong Zhu; Xiaoping Wu; Xiaoyu Gao Journal: Nan Fang Yi Ke Da Xue Xue Bao Date: 2018-01-30
Authors: Frederick J A Meijer; Anouke van Rumund; Anil M Tuladhar; Marjolein B Aerts; Imke Titulaer; Rianne A J Esselink; Bastiaan R Bloem; Marcel M Verbeek; Bozena Goraj Journal: Neuroradiology Date: 2015-04-07 Impact factor: 2.804