| Literature DB >> 21058243 |
Fernanda Lacerda da Silva Machado1, Wallace Pacienza-Lima, Bartira Rossi-Bergmann, Lísia Mônica de Souza Gestinari, Mutue T Fujii, Joel Campos de Paula, Sônia Soares Costa, Norberto Peporine Lopes, Carlos Roland Kaiser, Angélica Ribeiro Soares.
Abstract
Investigation of the bioactive crude extracts from two populations of the red alga Laurencia dendroidea from the southeastern Brazilian coast led to the identification of five sesquiterpenes: (+)-obtusane (1), a triquinane derivative (2), (-)-elatol (3), obtusol (4), and cartilagineol (5). An antileishmanial bioassay against Leishmania amazonensis was conducted for crude lipophilic extracts and for sesquiterpenes 2, 3, and 4. Compounds 3 and 4 displayed in vitro and in vivo leishmanicidal activity and very low cytotoxicity. © Georg Thieme Verlag KG Stuttgart · New York.Entities:
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Year: 2010 PMID： 21058243 DOI： 10.1055/s-0030-1250526
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352