Literature DB >> 21056912

Cytotoxic mechanisms may play a role in the local immune response in the central nervous system in neuroborreliosis.

Marika Nordberg1, Pia Forsberg, Anna Johansson, Dag Nyman, Christian Jansson, Jan Ernerudh, Christina Ekerfelt.   

Abstract

Aiming to investigate the role of cytotoxic mechanisms in neuroborreliosis (NB), the cytokines IL-2, IL-7, IL-10, IL-12p70, IL-15, GM-CSF and the Th17-cytokine IL-17 were analyzed in cerebrospinal fluid (CSF) and plasma from NB-patients. NB-patients showed increased levels in CSF compared to controls of all analyzed cytokines except IL-15 but not in plasma. Blood lymphocytes from three NB-patients showed functional cytotoxicity in response to autologous Borrelia-infected macrophages. The findings support a role for cytotoxic mechanisms in the local immune response in NB and in addition suggest an increase of IL-17.
Copyright © 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 21056912     DOI： 10.1016/j.jneuroim.2010.09.028

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  10 in total

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Authors:  Zizhen Kang; Liping Liu; Roo Spangler; Charles Spear; Chenhui Wang; Muhammet Fatih Gulen; Mike Veenstra; Wenjun Ouyang; Richard M Ransohoff; Xiaoxia Li
Journal:  J Neurosci       Date:  2012-06-13       Impact factor: 6.167

2.  A possible role for inflammation in mediating apoptosis of oligodendrocytes as induced by the Lyme disease spirochete Borrelia burgdorferi.

Authors:  Geeta Ramesh; Shemi Benge; Bapi Pahar; Mario T Philipp
Journal:  J Neuroinflammation       Date:  2012-04-23       Impact factor: 8.322

3.  Doxycycline-mediated effects on persistent symptoms and systemic cytokine responses post-neuroborreliosis: a randomized, prospective, cross-over study.

Authors:  Johanna Sjöwall; Anna Ledel; Jan Ernerudh; Christina Ekerfelt; Pia Forsberg
Journal:  BMC Infect Dis       Date:  2012-08-10       Impact factor: 3.090

4.  Adaptive and innate immune responsiveness to Borrelia burgdorferi sensu lato in exposed asymptomatic children and children with previous clinical Lyme borreliosis.

Authors:  Barbro H Skogman; Sandra Hellberg; Christina Ekerfelt; Maria C Jenmalm; Pia Forsberg; Johnny Ludvigsson; Sven Bergström; Jan Ernerudh
Journal:  Clin Dev Immunol       Date:  2011-12-05

5.  Indications of Th1 and Th17 responses in cerebrospinal fluid from patients with Lyme neuroborreliosis: a large retrospective study.

Authors:  Anna J Henningsson; Ivar Tjernberg; Bo-Eric Malmvall; Pia Forsberg; Jan Ernerudh
Journal:  J Neuroinflammation       Date:  2011-04-20       Impact factor: 8.322

Review 6.  Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain.

Authors:  Geeta Ramesh; Andrew G MacLean; Mario T Philipp
Journal:  Mediators Inflamm       Date:  2013-08-12       Impact factor: 4.711

7.  Early cytokine release in response to live Borrelia burgdorferi Sensu Lato Spirochetes is largely complement independent.

Authors:  Kerstin Sandholm; Anna J Henningsson; Susanne Säve; Sven Bergström; Pia Forsberg; Nina Jonsson; Jan Ernerudh; Kristina N Ekdahl
Journal:  PLoS One       Date:  2014-09-29       Impact factor: 3.240

8.  Intrathecal Th17- and B cell-associated cytokine and chemokine responses in relation to clinical outcome in Lyme neuroborreliosis: a large retrospective study.

Authors:  Paula Gyllemark; Pia Forsberg; Jan Ernerudh; Anna J Henningsson
Journal:  J Neuroinflammation       Date:  2017-02-01       Impact factor: 8.322

9.  Th1 and Th17 but no Th2-related cytokine spectrum in the cerebrospinal fluid of children with Borrelia-related facial nerve palsy.

Authors:  Zuzana Liba; Jana Kayserova; Vladimir Komarek
Journal:  Fluids Barriers CNS       Date:  2013-10-04

10.  Cerebrospinal fluid cytokines in Lyme neuroborreliosis.

Authors:  Annukka Pietikäinen; Mikael Maksimow; Tommi Kauko; Saija Hurme; Marko Salmi; Jukka Hytönen
Journal:  J Neuroinflammation       Date:  2016-10-18       Impact factor: 8.322
  10 in total

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