| Literature DB >> 21055734 |
D H Canaday1, C J Burant, L Jones, H Aung, L Woc-Colburn, D D Anthony.
Abstract
Individuals with chronic HCV infection have impaired response to vaccine, though the etiology remains to be elucidated. Dendritic cells (DC) and monocytes (MN) provide antigen uptake, processing, presentation, and costimulatory functions necessary to achieve optimal immune responses. The integrity of antigen processing and presentation function within these antigen presenting cells (APC) in the setting of HCV infection has been unclear. We used a novel T cell hybridoma system that specifically measures MHC-II antigen processing and presentation function of human APC. Results demonstrate MHC-II antigen processing and presentation function is preserved in both myeloid DC (mDC) and MN in the peripheral blood of chronically HCV-infected individuals, and indicates that an alteration in this function does not likely underlie the defective HCV-infected host response to vaccination. Published by Elsevier Inc.Entities:
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Year: 2010 PMID： 21055734 PMCID： PMC3005840 DOI： 10.1016/j.cellimm.2010.10.003
Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868