| Literature DB >> 21055613 |
Jane L Wang1, Jeffery Carter, James R Kiefer, Ravi G Kurumbail, Jennifer L Pawlitz, David Brown, Susan J Hartmann, Matthew J Graneto, Karen Seibert, John J Talley.
Abstract
In this manuscript, we report the discovery of the substituted 2-trifluoromethyl-2H-benzopyran-3-carboxylic acids as a novel series of potent and selective cyclooxygenase-2 (COX-2) inhibitors. 5c-(S) (SD-8381) was advanced into clinical studies due to its superior in vivo potency. The high plasma protein binding (>99% bound) of 5c-(S) has resulted in a surprisingly long human half life t(1/2)=360 h.Entities:
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Year: 2010 PMID： 21055613 DOI： 10.1016/j.bmcl.2010.07.053
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823