OBJECTIVE: We sought to assess long-term neurodevelopment of children who were treated prenatally as part of the Eurofoetus randomized controlled trial. STUDY DESIGN: The study population was composed of 128 cases of twin-to-twin transfusion syndrome (TTTS) included and followed up in France. Survivors were evaluated by standardized neurological examination and by Ages and Stages Questionnaires (ASQ). Primary outcome was a composite of death and major neurological impairment. RESULTS: A total of 120 children (47%) were alive at the age of 6 months and were followed up to the age of 6 years. At the time of diagnosis, only treatment and Quintero stage were predictors of a poor outcome (hazard ratio, 0.61; 95% confidence interval, 0.41-0.90; P = .01 and hazard ratio, 3.23; 95% confidence interval, 2.19-4.76; P < .001, respectively). Children treated by fetoscopic selective laser coagulation (FSLC) had higher ASQ scores at the end of follow-up (P = .04). CONCLUSION:FSLC was significantly associated with a reduction of the risk of death or long-term major neurological impairment at the time of diagnosis and treatment.
RCT Entities:
OBJECTIVE: We sought to assess long-term neurodevelopment of children who were treated prenatally as part of the Eurofoetus randomized controlled trial. STUDY DESIGN: The study population was composed of 128 cases of twin-to-twin transfusion syndrome (TTTS) included and followed up in France. Survivors were evaluated by standardized neurological examination and by Ages and Stages Questionnaires (ASQ). Primary outcome was a composite of death and major neurological impairment. RESULTS: A total of 120 children (47%) were alive at the age of 6 months and were followed up to the age of 6 years. At the time of diagnosis, only treatment and Quintero stage were predictors of a poor outcome (hazard ratio, 0.61; 95% confidence interval, 0.41-0.90; P = .01 and hazard ratio, 3.23; 95% confidence interval, 2.19-4.76; P < .001, respectively). Children treated by fetoscopic selective laser coagulation (FSLC) had higher ASQ scores at the end of follow-up (P = .04). CONCLUSION: FSLC was significantly associated with a reduction of the risk of death or long-term major neurological impairment at the time of diagnosis and treatment.
Authors: Asma Khalil; Helen Perry; James Duffy; Keith Reed; Ahmet Baschat; Jan Deprest; Kurt Hecher; Liesbeth Lewi; Enrico Lopriore; Dick Oepkes Journal: Trials Date: 2017-07-14 Impact factor: 2.279
Authors: Lisa Hui; Heather C Wick; Kenneth J Moise; Anthony Johnson; Francois Luks; Sina Haeri; Kirby L Johnson; Diana W Bianchi Journal: Prenat Diagn Date: 2013-06-04 Impact factor: 3.050
Authors: Christie Bolch; Michael Fahey; Dinah Reddihough; Katrina Williams; Susan Reid; Angela Guzys; Stephen Cole; Andrew Edwards; Alison Fung; Ryan Hodges; Ricardo Palma-Dias; Mark Teoh; Susan Walker Journal: BMC Pediatr Date: 2018-08-01 Impact factor: 2.125
Authors: Carmen J Marsit; Devin C Koestler; Debra Watson-Smith; Charlotte M Boney; James F Padbury; Francois Luks Journal: Clin Epigenetics Date: 2013-10-03 Impact factor: 6.551