| Literature DB >> 21055422 |
Andrew J Tarr1, Kristina A McLinden, Dinko Kranjac, Rachel A Kohman, Wellington Amaral, Gary W Boehm.
Abstract
An acute LPS challenge immediately following day 1 of shuttlebox training triggered exacerbated central IL-1β production and disrupted memory consolidation and/or further acquisition of the task in 18-month-old mice, compared to 4-month-old controls. These deficits cannot be attributed to alterations in sickness behavior. The findings suggest that age and immune activation combine to impair learning and memory consolidation processes, and that increased central IL-1β production may play a role.Entities:
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Year: 2010 PMID： 21055422 DOI： 10.1016/j.bbr.2010.10.036
Source DB: PubMed Journal: Behav Brain Res ISSN： 0166-4328 Impact factor: 3.332