Literature DB >> 21051862

Growth factors in induction of epithelial-mesenchymal transition and metastasis.

Nur Akmarina B M Said1, Elizabeth D Williams.   

Abstract

Epithelial to mesenchymal transition (EMT) has gained widespread acceptance over recent years as a mechanism by which normally sessile epithelial tumour cells can move away from the primary tumour and metastasize. This review article examines the role of a number of growth factors in inducing EMT, and the reverse process mesenchymal to epithelial transition. Unique and common intracellular signalling pathways are highlighted. A comprehensive understanding of the regulation of EMT will be critical in manipulating this process to develop novel anti-metastasis therapies.
Copyright © 2010 S. Karger AG, Basel.

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Year:  2010        PMID： 21051862     DOI： 10.1159/000320360

Source DB:  PubMed          Journal:  Cells Tissues Organs        ISSN： 1422-6405            Impact factor:   2.481


  32 in total

1.  Signal transducers and activators of transcription 3 (STAT3) directly regulates cytokine-induced fascin expression and is required for breast cancer cell migration.

Authors:  Marylynn Snyder; Xin-Yun Huang; J Jillian Zhang
Journal:  J Biol Chem       Date:  2011-09-20       Impact factor: 5.157

2.  Immunolocalization of vimentin, keratin 17, Ki-67, involucrin, β-catenin and E-cadherin in cutaneous squamous cell carcinoma.

Authors:  Yan-Ju Lan; Huan Chen; Jia-Qi Chen; Qiu-Hua Lei; Min Zheng; Zhe-Ren Shao
Journal:  Pathol Oncol Res       Date:  2013-09-04       Impact factor: 3.201

3.  Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy.

Authors:  Bingxue Shang; Gaochuan Zhang; Yanyan Pan; Quansheng Zhou
Journal:  Cancer Microenviron       Date:  2012-05-17

4.  MicroRNA-429 inhibits gastric cancer migration and invasion through the downregulation of specificity protein 1.

Authors:  Jingbin Ni; Yisha Yang; Di Liu; Hui Sun; Shimao Jin; Jingying Li
Journal:  Oncol Lett       Date:  2017-03-17       Impact factor: 2.967

5.  A humanized tissue-engineered in vivo model to dissect interactions between human prostate cancer cells and human bone.

Authors:  Parisa Hesami; Boris M Holzapfel; Anna Taubenberger; Martine Roudier; Ladan Fazli; Shirly Sieh; Laure Thibaudeau; Laura S Gregory; Dietmar W Hutmacher; Judith A Clements
Journal:  Clin Exp Metastasis       Date:  2014-02-08       Impact factor: 5.150

6.  TGF-β1 and TNF-α synergistically induce epithelial to mesenchymal transition of breast cancer cells by enhancing TAK1 activation.

Authors:  Sheng-Jun Liao; Jing Luo; Dong Li; Yuan-Hong Zhou; Bin Yan; Jing-Jing Wei; Jian-Cheng Tu; Yi-Rong Li; Gui-Mei Zhang; Zuo-Hua Feng
Journal:  J Cell Commun Signal       Date:  2019-02-09       Impact factor: 5.782

Review 7.  Integration of molecules to construct the processes of conceptus implantation to the maternal endometrium.

Authors:  K Imakawa; R Bai; K Kusama
Journal:  J Anim Sci       Date:  2018-06-29       Impact factor: 3.159

8.  Tumor-suppressing effects of microRNA-429 in human renal cell carcinoma via the downregulation of Sp1.

Authors:  Deyao Wu; Xiaobing Niu; Huixing Pan; Yunfeng Zhou; Zichun Zhang; Ping Qu; Jian Zhou
Journal:  Oncol Lett       Date:  2016-08-05       Impact factor: 2.967

9.  A signal transducer and activator of transcription 3·Nuclear Factor κB (Stat3·NFκB) complex is necessary for the expression of fascin in metastatic breast cancer cells in response to interleukin (IL)-6 and tumor necrosis factor (TNF)-α.

Authors:  Marylynn Snyder; Jianyun Huang; Xin-Yun Huang; J Jillian Zhang
Journal:  J Biol Chem       Date:  2014-09-11       Impact factor: 5.157

Review 10.  Controversies around epithelial-mesenchymal plasticity in cancer metastasis.

Authors:  Elizabeth D Williams; Dingcheng Gao; Andrew Redfern; Erik W Thompson
Journal:  Nat Rev Cancer       Date:  2019-10-30       Impact factor: 60.716
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