OBJECTIVE: To evaluate the influence of biopsy-proven celiac disease (BPCD) on somatic development and metabolic parameters in children with type 1 diabetes mellitus (T1DM) in a multicenter survey. STUDY DESIGN: Within the Diabetes Patienten Verlaufsdokumentationssystem-Wiss project, data of 41 951 patients with T1DM, aged <20 years (52% males, mean age 13.9 years; mean duration of diabetes 5.5 years) were collected in 297 centers in Germany and Austria from 1995 to 2009. RESULTS: The number of BPCD (0.6% in 1995; 1.3% in 2008) has increased over time. Patients with BPCD were significantly younger at diabetes onset (5.9 vs 8.3 years), had a significantly lower weight standard deviation score (SDS); (0.20 vs 0.43) and height SDS (-0.28 vs -0.03) (P < .001, each) compared with patients without celiac disease. No differences were found in hemoglobin A1c or numbers of severe hypoglycemia. In a subgroup of 9805 patients (183 with BPCD) significantly lower height and weight SDS (P < .001) were still found after a 5-year follow-up. CONCLUSIONS: Screening for celiac disease is important in children with T1DM to prevent persistent growth failure.
OBJECTIVE: To evaluate the influence of biopsy-proven celiac disease (BPCD) on somatic development and metabolic parameters in children with type 1 diabetes mellitus (T1DM) in a multicenter survey. STUDY DESIGN: Within the Diabetes Patienten Verlaufsdokumentationssystem-Wiss project, data of 41 951 patients with T1DM, aged <20 years (52% males, mean age 13.9 years; mean duration of diabetes 5.5 years) were collected in 297 centers in Germany and Austria from 1995 to 2009. RESULTS: The number of BPCD (0.6% in 1995; 1.3% in 2008) has increased over time. Patients with BPCD were significantly younger at diabetes onset (5.9 vs 8.3 years), had a significantly lower weight standard deviation score (SDS); (0.20 vs 0.43) and height SDS (-0.28 vs -0.03) (P < .001, each) compared with patients without celiac disease. No differences were found in hemoglobin A1c or numbers of severe hypoglycemia. In a subgroup of 9805 patients (183 with BPCD) significantly lower height and weight SDS (P < .001) were still found after a 5-year follow-up. CONCLUSIONS: Screening for celiac disease is important in children with T1DM to prevent persistent growth failure.
Authors: Belinda S Lennerz; Anna Barton; Richard K Bernstein; R David Dikeman; Carrie Diulus; Sarah Hallberg; Erinn T Rhodes; Cara B Ebbeling; Eric C Westman; William S Yancy; David S Ludwig Journal: Pediatrics Date: 2018-05-07 Impact factor: 7.124
Authors: Beate Karges; Thomas Meissner; Andrea Icks; Thomas Kapellen; Reinhard W Holl Journal: Nat Rev Endocrinol Date: 2011-11-29 Impact factor: 43.330
Authors: Clemens Kamrath; Sascha R Tittel; Desiree Dunstheimer; Elke Fröhlich-Reiterer; Markus Freff; Claudia Böttcher; Nadine Scheffler; Stefanie Lenze; Elke Gericke; Susanne Thiele; Reinhard W Holl Journal: Diabetologia Date: 2022-04-30 Impact factor: 10.460
Authors: Belinda S Lennerz; Andrew P Koutnik; Svetlana Azova; Joseph I Wolfsdorf; David S Ludwig Journal: J Clin Invest Date: 2021-01-04 Impact factor: 14.808
Authors: Kaziwe Mollazadegan; Maria Kugelberg; Scott M Montgomery; David S Sanders; Johnny Ludvigsson; Jonas F Ludvigsson Journal: Diabetes Care Date: 2012-09-10 Impact factor: 19.112