Literature DB >> 2105097

G-proteins (Gi, Go) in the basal ganglia of control and schizophrenic brain.

F Okada1, T J Crow, G W Roberts.   

Abstract

We detected the existence of Gi (the inhibitory G-protein) or Go (a similar G-protein of unknown function) in the striatum of control and schizophrenic brains utilizing pertussis toxin-catalyzed ADP ribosylation. The level of Gi/Go was significantly decreased by 42% in the putamen of the left hemisphere in schizophrenics; caudate head and globus pallidus levels were unchanged. Decreased Gi or Go may underlie enhanced dopamine function in the schizophrenic brain.

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Year:  1990        PMID： 2105097     DOI： 10.1007/bf01245133

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  30 in total

1.  Antiserum raised against residues 159-168 of the guanine nucleotide-binding protein Gi3-alpha reacts with ependymal cells and some neurons in the rat brain containing cholecystokinin- or cholecystokinin- and tyrosine 3-hydroxylase-like immunoreactivities.

Authors:  R Cortés; T Hökfelt; M Schalling; M Goldstein; P Goldsmith; A Spiegel; C Unson; J Walsh
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

2.  Identification of a new GTP-binding protein. A Mr = 43,000 substrate for pertussis toxin.

Authors:  R Iyengar; K A Rich; J T Herberg; D Grenet; S Mumby; J Codina
Journal:  J Biol Chem       Date:  1987-07-05       Impact factor: 5.157

3.  The human genome encodes at least three non-allellic G proteins with alpha i-type subunits.

Authors:  W N Suki; J Abramowitz; R Mattera; J Codina; L Birnbaumer
Journal:  FEBS Lett       Date:  1987-08-10       Impact factor: 4.124

4.  Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities.

Authors:  T Katada; M Oinuma; M Ui
Journal:  J Biol Chem       Date:  1986-06-25       Impact factor: 5.157

5.  The dopamine hypothesis survives, but there must be a way ahead.

Authors:  T J Crow
Journal:  Br J Psychiatry       Date:  1987-10       Impact factor: 9.319

6.  Binding of 3H-neuroleptics and 3H-apomorphine in schizophrenic brains.

Authors:  T Lee; P Seeman; W W Tourtellotte; I J Farley; O Hornykeiwicz
Journal:  Nature       Date:  1978-08-31       Impact factor: 49.962

7.  Diagnostic criteria for use in psychiatric research.

Authors:  J P Feighner; E Robins; S B Guze; R A Woodruff; G Winokur; R Munoz
Journal:  Arch Gen Psychiatry       Date:  1972-01

8.  Spontaneous involuntary disorders of movement: their prevalence, severity, and distribution in chronic schizophrenics with and without treatment with neuroleptics.

Authors:  D G Owens; E C Johnstone; C D Frith
Journal:  Arch Gen Psychiatry       Date:  1982-04

9.  Increased brain dopamine and dopamine receptors in schizophrenia.

Authors:  A V Mackay; L L Iversen; M Rossor; E Spokes; E Bird; A Arregui; I Creese; S H Synder
Journal:  Arch Gen Psychiatry       Date:  1982-09

10.  Coupling of dopamine D1 recognition sites with adenylate cyclase in nuclei accumbens and caudatus of schizophrenics.

Authors:  M Memo; J E Kleinman; I Hanbauer
Journal:  Science       Date:  1983-09-23       Impact factor: 47.728
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  7 in total

1.  Effects of chronic treatment of haloperidol and clozapine on levels of G-protein subunits in rat striatum.

Authors:  S K Gupta; R K Mishra
Journal:  J Mol Neurosci       Date:  1992       Impact factor: 3.444

Review 2.  Molecular mechanisms of go signaling.

Authors:  Meisheng Jiang; Neil S Bajpayee
Journal:  Neurosignals       Date:  2009-02-12

3.  Differential effects of the antipsychotics haloperidol and clozapine on G protein measures in mononuclear leukocytes of patients with schizophrenia.

Authors:  S Avissar; G Roitman; G Schreiber
Journal:  Cell Mol Neurobiol       Date:  2001-12       Impact factor: 5.046

4.  Different forms of Go alpha mRNA arise by alternative splicing of transcripts from a single gene on human chromosome 16.

Authors:  J J Murtagh; R Eddy; T B Shows; J Moss; M Vaughan
Journal:  Mol Cell Biol       Date:  1991-02       Impact factor: 4.272

5.  G proteins (Gi, Go) in the medial temporal lobe in schizophrenia: preliminary report of a neurochemical correlate of structural change.

Authors:  F Okada; T J Crow; G W Roberts
Journal:  J Neural Transm Gen Sect       Date:  1991

6.  Impaired interhemispheric integration in brain oxygenation and hemodynamics in schizophrenia.

Authors:  F Okada; Y Tokumitsu; Y Hoshi; M Tamura
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1994       Impact factor: 5.270

7.  Reduced concentrations of the alpha-subunit of GTP-binding protein Go in schizophrenic brain.

Authors:  F Okada; Y Tokumitsu; N Takahashi; T J Crow; G W Roberts
Journal:  J Neural Transm Gen Sect       Date:  1994
  7 in total

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