| Literature DB >> 21050127 |
Yong Zhang1, Dongmei Yan, Shuangli Zhu, Ning Wen, Li Li, Haiyan Wang, Jianfeng Liu, Xufang Ye, Zhengrong Ding, Dongyan Wang, Hui Zhu, Li Chen, Xiaohui Hou, Hongqiu An, Xiaofeng Liang, Huiming Luo, Olen Kew, Wenbo Xu.
Abstract
In China, 5 patients with acute flaccid paralysis (AFP) associated with type 2 vaccine-derived poliovirus (VDPV) were identified by an AFP surveillance system from 1996 through 2009. A maximum-likelihood tree shows that all 5 Chinese VDPVs were independent. These 5 VDPVs were 100-216 d old according to the number of synonymous substitutions per synonymous site and 176-292 d old according to the number of substitutions per site. This result indicates limited virus replication since the administration of the initiating oral polio vaccine (OPV) dose, which is consistent with the rapid evolution rate of poliovirus genomes. The above-mentioned VDPVs have important implications in the global polio eradication initiative. Localized, limited, and transient circulation may be typical of OPVs; hence, independent VDPVs could be found because of the large population and excellent surveillance system, which permitted early detection and response, but sustained transmission was limited because of high population immunity.Entities:
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Year: 2010 PMID： 21050127 DOI： 10.1086/657410
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226