Literature DB >> 21050125

Comparative analysis of virulence and toxin expression of global community-associated methicillin-resistant Staphylococcus aureus strains.

Min Li1, Gordon Y C Cheung, Jinhui Hu, Decheng Wang, Hwang-Soo Joo, Frank R Deleo, Michael Otto.   

Abstract

The current pandemic of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) skin infections is caused by several genetically unrelated clones. Here, we analyzed virulence of globally occurring CA-MRSA strains in a rabbit skin infection model. We used rabbits because neutrophils from this animal species have relatively high sensitivity to Panton-Valentine leukocidin (PVL), a toxin epidemiologically correlated with many CA-MRSA infections. Virulence in the rabbit model correlated with in vitro neutrophil lysis and transcript levels of phenol-soluble modulin α and α-toxin, but not PVL genes. Furthermore, abscesses caused by USA300 and its PVL-negative progenitor USA500 were comparatively large and similar in size, suggesting that PVL has played a limited role in the evolution of USA300 virulence in the context of skin infections. Our study indicates a major but not exclusive impact of virulence on the epidemiological success of USA300 and other CA-MRSA strains and emphasizes the importance of core genome-encoded toxins in CA-MRSA skin infections.

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Year:  2010        PMID： 21050125      PMCID： PMC3058913          DOI： 10.1086/657419

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  43 in total

1.  From the Centers for Disease Control and Prevention. Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus--Minnesota and North Dakota, 1997-1999.

Authors: 
Journal:  JAMA       Date:  1999 Sep 22-29       Impact factor: 56.272

2.  Community-associated MRSA--resistance and virulence converge.

Authors:  Henry F Chambers
Journal:  N Engl J Med       Date:  2005-04-07       Impact factor: 91.245

3.  Roles of 34 virulence genes in the evolution of hospital- and community-associated strains of methicillin-resistant Staphylococcus aureus.

Authors:  Binh An Diep; Heather A Carleton; Richard F Chang; George F Sensabaugh; Francoise Perdreau-Remington
Journal:  J Infect Dis       Date:  2006-04-21       Impact factor: 5.226

4.  Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?

Authors:  Jovanka M Voyich; Michael Otto; Barun Mathema; Kevin R Braughton; Adeline R Whitney; Diane Welty; R Daniel Long; David W Dorward; Donald J Gardner; Gérard Lina; Barry N Kreiswirth; Frank R DeLeo
Journal:  J Infect Dis       Date:  2006-11-02       Impact factor: 5.226

5.  Interaction of the cyclic antimicrobial cationic peptide bactenecin with the outer and cytoplasmic membrane.

Authors:  M Wu; R E Hancock
Journal:  J Biol Chem       Date:  1999-01-01       Impact factor: 5.157

6.  Transmembrane beta-barrel of staphylococcal alpha-toxin forms in sensitive but not in resistant cells.

Authors:  A Valeva; I Walev; M Pinkernell; B Walker; H Bayley; M Palmer; S Bhakdi
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

7.  Methicillin-resistant S. aureus infections among patients in the emergency department.

Authors:  Gregory J Moran; Anusha Krishnadasan; Rachel J Gorwitz; Gregory E Fosheim; Linda K McDougal; Roberta B Carey; David A Talan
Journal:  N Engl J Med       Date:  2006-08-17       Impact factor: 91.245

8.  Insights into mechanisms used by Staphylococcus aureus to avoid destruction by human neutrophils.

Authors:  Jovanka M Voyich; Kevin R Braughton; Daniel E Sturdevant; Adeline R Whitney; Battouli Saïd-Salim; Stephen F Porcella; R Daniel Long; David W Dorward; Donald J Gardner; Barry N Kreiswirth; James M Musser; Frank R DeLeo
Journal:  J Immunol       Date:  2005-09-15       Impact factor: 5.422

9.  Global changes in gene expression by human polymorphonuclear leukocytes during receptor-mediated phagocytosis: cell fate is regulated at the level of gene expression.

Authors:  Scott D Kobayashi; Jovanka M Voyich; Cassandra L Buhl; Robert M Stahl; Frank R DeLeo
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-30       Impact factor: 11.205

10.  Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia.

Authors:  G Lina; Y Piémont; F Godail-Gamot; M Bes; M O Peter; V Gauduchon; F Vandenesch; J Etienne
Journal:  Clin Infect Dis       Date:  1999-11       Impact factor: 9.079
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  96 in total

1.  Staphylococcus aureus leucocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo.

Authors:  Francis Alonzo; Meredith A Benson; John Chen; Richard P Novick; Bo Shopsin; Victor J Torres
Journal:  Mol Microbiol       Date:  2011-12-20       Impact factor: 3.501

2.  TCA cycle inactivation in Staphylococcus aureus alters nitric oxide production in RAW 264.7 cells.

Authors:  Chandirasegaran Massilamany; Arunakumar Gangaplara; Donald J Gardner; James M Musser; David Steffen; Greg A Somerville; Jay Reddy
Journal:  Mol Cell Biochem       Date:  2011-04-26       Impact factor: 3.396

Review 3.  Virulence strategies of the dominant USA300 lineage of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA).

Authors:  Lance R Thurlow; Gauri S Joshi; Anthony R Richardson
Journal:  FEMS Immunol Med Microbiol       Date:  2012-03-05

Review 4.  Innate Immune Signaling Activated by MDR Bacteria in the Airway.

Authors:  Dane Parker; Danielle Ahn; Taylor Cohen; Alice Prince
Journal:  Physiol Rev       Date:  2016-01       Impact factor: 37.312

5.  The impact of α-toxin on host cell plasma membrane permeability and cytokine expression during human blood infection by CA-MRSA USA300.

Authors:  Tyler K Nygaard; Kyler B Pallister; Oliwia W Zurek; Jovanka M Voyich
Journal:  J Leukoc Biol       Date:  2013-09-11       Impact factor: 4.962

6.  Simulated antibiotic exposures in an in vitro hollow-fiber infection model influence toxin gene expression and production in community-associated methicillin-resistant Staphylococcus aureus strain MW2.

Authors:  Solen Pichereau; Madhulatha Pantrangi; William Couet; Cedric Badiou; Gerard Lina; Sanjay K Shukla; Warren E Rose
Journal:  Antimicrob Agents Chemother       Date:  2011-11-07       Impact factor: 5.191

Review 7.  The potential use of toxin antibodies as a strategy for controlling acute Staphylococcus aureus infections.

Authors:  Gordon Y C Cheung; Michael Otto
Journal:  Expert Opin Ther Targets       Date:  2012-04-25       Impact factor: 6.902

8.  Hydrogel Retaining Toxin-Absorbing Nanosponges for Local Treatment of Methicillin-Resistant Staphylococcus aureus Infection.

Authors:  Fei Wang; Weiwei Gao; Soracha Thamphiwatana; Brian T Luk; Pavimol Angsantikul; Qiangzhe Zhang; Che-Ming J Hu; Ronnie H Fang; Jonathan A Copp; Dissaya Pornpattananangkul; Weiyue Lu; Liangfang Zhang
Journal:  Adv Mater       Date:  2015-04-30       Impact factor: 30.849

9.  Epicutaneous model of community-acquired Staphylococcus aureus skin infections.

Authors:  Ranjani Prabhakara; Oded Foreman; Roberto De Pascalis; Gloria M Lee; Roger D Plaut; Stanley Y Kim; Scott Stibitz; Karen L Elkins; Tod J Merkel
Journal:  Infect Immun       Date:  2013-02-04       Impact factor: 3.441

10.  Identification of a Novel Gene Associated with High-Level β-Lactam Resistance in Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Strain Mu3 and Methicillin-Resistant S. aureus Strain N315.

Authors:  Miki Matsuo; Norio Yamamoto; Tomomi Hishinuma; Keiichi Hiramatsu
Journal:  Antimicrob Agents Chemother       Date:  2019-01-29       Impact factor: 5.191
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