| Literature DB >> 21048354 |
Tomohiro Minakawa1, Kazufumi Toume, Firoj Ahmed, Samir Kumar Sadhu, Takashi Ohtsuki, Midori A Arai, Masami Ishibashi.
Abstract
In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2″,3″:7,8)-furanoflavanone (1), along with six known flavonoids (2-7). Two of the compounds significantly overcame TRAIL-resistance in human gastric adenocarcinoma (AGS) cell lines.Entities:
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Year: 2010 PMID： 21048354 DOI： 10.1248/cpb.58.1549
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645