| Literature DB >> 2104788 |
E W St Clair1, C C Query, R Bentley, J D Keene, R P Polisson, N B Allen, D S Caldwell, J R Rice, C Cox, D S Pisetsky.
Abstract
To determine the specificity of antibodies to the (U1) ribonucleoprotein antigen in systemic lupus erythematosus (SLE), patient sera were tested for binding to a recombinant human 70K antigen. By solid-phase immunoassay, we detected anti-70K reactivity in sera from 31 of 96 patients with systemic lupus erythematosus (SLE), demonstrating that anti-70K antibodies may occur in patients with SLE as well as other clinical diagnoses. In sequential sera from 2 of these patients, we found that anti-70K binding varied dramatically over the course of disease. The changes in anti-70K antibody levels did not correlate with clinical events nor evolving antibody reactivity with the Sm-specific antigens.Entities:
Mesh：
Substances：
Year: 1990 PMID： 2104788 DOI： 10.1016/0090-1229(90)90088-8
Source DB: PubMed Journal: Clin Immunol Immunopathol ISSN： 0090-1229