Literature DB >> 21047780

Mesencephalic astrocyte-derived neurotrophic factor (MANF) has a unique mechanism to rescue apoptotic neurons.

Maarit Hellman1, Urmas Arumäe, Li-ying Yu, Päivi Lindholm, Johan Peränen, Mart Saarma, Perttu Permi.   

Abstract

Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects neurons and repairs the Parkinson disease-like symptoms in a rat 6-hydroxydopamine model. We show a three-dimensional solution structure of human MANF that differs drastically from other neurotrophic factors. Remarkably, the C-terminal domain of MANF (C-MANF) is homologous to the SAP domain of Ku70, a well known inhibitor of proapoptotic Bax (Bcl-2-associated X protein). Cellular studies confirm that MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.

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Year:  2010        PMID： 21047780      PMCID： PMC3024763          DOI： 10.1074/jbc.M110.146738

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  32 in total

1.  1H, 13C and 15N resonance assignments of the human mesencephalic astrocyte-derived neurotrophic factor.

Authors:  Maarit Hellman; Johan Peränen; Mart Saarma; Perttu Permi
Journal:  Biomol NMR Assign       Date:  2010-07-09       Impact factor: 0.746

2.  Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation.

Authors:  Avigail D Amsel; Moran Rathaus; Noam Kronman; Haim Y Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-24       Impact factor: 11.205

3.  Touring protein fold space with Dali/FSSP.

Authors:  L Holm; C Sander
Journal:  Nucleic Acids Res       Date:  1998-01-01       Impact factor: 16.971

Review 4.  A short guided tour through functional and structural features of saposin-like proteins.

Authors:  Heike Bruhn
Journal:  Biochem J       Date:  2005-07-15       Impact factor: 3.857

5.  Essential postmitochondrial function of p53 uncovered in DNA damage-induced apoptosis in neurons.

Authors:  A E Vaughn; M Deshmukh
Journal:  Cell Death Differ       Date:  2007-01-12       Impact factor: 15.828

Review 6.  Neurotrophin-regulated signalling pathways.

Authors:  Louis F Reichardt
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-09-29       Impact factor: 6.237

7.  Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2.

Authors:  Michael D Tibbetts; Eric N Shiozaki; Lichuan Gu; E Robert McDonald; Wafik S El-Deiry; Yigong Shi
Journal:  Structure       Date:  2004-12       Impact factor: 5.006

8.  BAX is required for neuronal death after trophic factor deprivation and during development.

Authors:  T L Deckwerth; J L Elliott; C M Knudson; E M Johnson; W D Snider; S J Korsmeyer
Journal:  Neuron       Date:  1996-09       Impact factor: 17.173

9.  Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.

Authors:  Päivi Lindholm; Merja H Voutilainen; Juha Laurén; Johan Peränen; Veli-Matti Leppänen; Jaan-Olle Andressoo; Maria Lindahl; Sanna Janhunen; Nisse Kalkkinen; Tõnis Timmusk; Raimo K Tuominen; Mart Saarma
Journal:  Nature       Date:  2007-07-05       Impact factor: 49.962

10.  ARMET is a soluble ER protein induced by the unfolded protein response via ERSE-II element.

Authors:  Naomi Mizobuchi; Jun Hoseki; Hiroshi Kubota; Shinya Toyokuni; Jun-ichi Nozaki; Motoko Naitoh; Akio Koizumi; Kazuhiro Nagata
Journal:  Cell Struct Funct       Date:  2007-05-14       Impact factor: 2.212
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  60 in total

1.  CDNF protects the nigrostriatal dopamine system and promotes recovery after MPTP treatment in mice.

Authors:  Mikko Airavaara; Brandon K Harvey; Merja H Voutilainen; Hui Shen; Jenny Chou; Päivi Lindholm; Maria Lindahl; Raimo K Tuominen; Mart Saarma; Barry Hoffer; Yun Wang
Journal:  Cell Transplant       Date:  2011-09-22       Impact factor: 4.064

2.  The preclinical discovery of amyotrophic lateral sclerosis drugs.

Authors:  Marcie A Glicksman
Journal:  Expert Opin Drug Discov       Date:  2011-10-25       Impact factor: 6.098

3.  MANF deletion abrogates early larval Caenorhabditis elegans stress response to tunicamycin and Pseudomonas aeruginosa.

Authors:  Jessica H Hartman; Christopher T Richie; Kacy L Gordon; Danielle F Mello; Priscila Castillo; April Zhu; Yun Wang; Barry J Hoffer; David R Sherwood; Joel N Meyer; Brandon K Harvey
Journal:  Eur J Cell Biol       Date:  2019-05-21       Impact factor: 4.492

Review 4.  Mesencephalic astrocyte-derived neurotrophic factor (MANF), a new player in endoplasmic reticulum diseases: structure, biology, and therapeutic roles.

Authors:  Yeawon Kim; Sun-Ji Park; Ying Maggie Chen
Journal:  Transl Res       Date:  2017-06-29       Impact factor: 7.012

5.  MANF improves the MPP+/MPTP-induced Parkinson's disease via improvement of mitochondrial function and inhibition of oxidative stress.

Authors:  Yigang Liu; Jingxing Zhang; Ming Jiang; Qiong Cai; Jianmin Fang; Lingjing Jin
Journal:  Am J Transl Res       Date:  2018-05-15       Impact factor: 4.060

Review 6.  Cerebral Dopamine Neurotrophic Factor: A Potential Therapeutic Agent for Parkinson's Disease.

Authors:  Tingting Tang; Yong Li; Qian Jiao; Xixun Du; Hong Jiang
Journal:  Neurosci Bull       Date:  2017-03-23       Impact factor: 5.203

Review 7.  Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson's disease.

Authors:  Tiago Martins Rodrigues; André Jerónimo-Santos; Tiago Fleming Outeiro; Ana Maria Sebastião; Maria José Diógenes
Journal:  Drugs Aging       Date:  2014-04       Impact factor: 3.923

8.  Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).

Authors:  Daniel A Cunha; Monia Cito; Fabio Arturo Grieco; Cristina Cosentino; Tatiana Danilova; Laurence Ladrière; Maria Lindahl; Andrii Domanskyi; Marco Bugliani; Piero Marchetti; Décio L Eizirik; Miriam Cnop
Journal:  J Biol Chem       Date:  2017-07-11       Impact factor: 5.157

9.  Mesencephalic astrocyte-derived neurotrophic factor (MANF) secretion and cell surface binding are modulated by KDEL receptors.

Authors:  Mark J Henderson; Christopher T Richie; Mikko Airavaara; Yun Wang; Brandon K Harvey
Journal:  J Biol Chem       Date:  2012-12-19       Impact factor: 5.157

10.  Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice.

Authors:  Su Yang; Shanshan Huang; Marta A Gaertig; Xiao-Jiang Li; Shihua Li
Journal:  Neuron       Date:  2014-01-22       Impact factor: 17.173
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