Literature DB >> 210477

The differential effect of lithium on noradrenaline- and dopamine-sensitive accumulation of cyclic AMP in guinea pig brain.

A Reches, R P Ebstein, R H Belmaker.   

Abstract

Lithium (Li) in its narrow therapeutic concentration range was found to inhibit only the noradrenaline- and not the dopamine-sensitive accumulation of cyclic AMP in guinea pig brain. The results suggest a pharmacological distinction between the anti-schizophrenic drugs that inhibit dopamine-sensitive cyclic AMP accumulation and Li, an antimanic agent that inhibits specifically only the noradrenaline-sensitive cyclic AMP accumulation.

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Year:  1978        PMID： 210477     DOI： 10.1007/bf00426910

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  18 in total

1.  The noradrenergic cyclic AMP generating system in the rat limbic forebrain and its stereospecificity for butaclamol.

Authors:  S E Robinson; F Sulser
Journal:  J Pharm Pharmacol       Date:  1976-08       Impact factor: 3.765

2.  Lithium inhibition of adrenaline-stimulated adenylate cyclase in humans.

Authors:  R Ebstein; R Belmaker; L Grunhaus; R Rimon
Journal:  Nature       Date:  1976-02-05       Impact factor: 49.962

3.  Drugs, neurotransmitters, and schizophrenia.

Authors:  S H Snyder; S P Banerjee; H I Yamamura; D Greenberg
Journal:  Science       Date:  1974-06-21       Impact factor: 47.728

4.  Effects of lithium on brain adenyl cyclase activity.

Authors:  J Forn; F G Valdecasas
Journal:  Biochem Pharmacol       Date:  1971-10       Impact factor: 5.858

5.  Propranolol and lithium-induced tremor.

Authors:  L Kirk; P C Baastrup; M Schou
Journal:  Lancet       Date:  1972-04-15       Impact factor: 79.321

6.  A simple, sensitive method for the assay of adenyl cyclase.

Authors:  G Krishna; B Weiss; B B Brodie
Journal:  J Pharmacol Exp Ther       Date:  1968-10       Impact factor: 4.030

7.  Controlled evaluation of lithium and chlorpromazine in the treatment of manic states: an interim report.

Authors:  G Johnson; S Gershon; L J Hekimian
Journal:  Compr Psychiatry       Date:  1968-11       Impact factor: 3.735

Review 8.  The catecholamine hypothesis of affective disorders: a review of supporting evidence.

Authors:  J J Schildkraut
Journal:  Am J Psychiatry       Date:  1965-11       Impact factor: 18.112

9.  Combined effect of lithium and flupenthixol on striatal adenylate cyclase.

Authors:  A Geisler; R Klysner
Journal:  Lancet       Date:  1977-02-19       Impact factor: 79.321

10.  A controlled study of lithium vs. chlorpromazine in acute schizophrenics.

Authors:  B Shopsin; S S Kim; S Gershon
Journal:  Br J Psychiatry       Date:  1971-10       Impact factor: 9.319
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