OBJECTIVE: To examine the frequency and distribution of antibodies against pandemic influenza A (H1N1 2009) [H1N1] in populations in Beijing and elucidate influencing factors. METHODS: In January 2010, a randomized serologic survey of pandemic influenza A (H1N1 2009) was carried out. Six districts that were randomly selected with a total of 4601 participants involved in the survey have their antibody level tested by hemagglutination inhibition assay. RESULTS: Among the 4601 participants, the overall seropositive rate for pandemic influenza A (H1N1 2009) antibodies was 31.7%. The seropositivity prevalence in participants who received the pandemic H1N1 vaccination was 60.9%. Only 53.1% of the pandemic influenza A (H1N1 2009) seropositive individuals who had not received the vaccination experienced respiratory tract infection symptoms. Multivariate logistic regression revealed that factors such as age, occupation, dwelling type, whether the participant's family included students in school, and the vaccination history with pandemic influenza A (H1N1 2009) were associated with antibody titers (p<0.05). CONCLUSIONS: Our data indicated that almost 30.0% of the residents had appropriate antibody titers against pandemic influenza A (H1N1 2009) in Beijing, and these titers may provide an immune barrier.
OBJECTIVE: To examine the frequency and distribution of antibodies against pandemic influenza A (H1N1 2009) [H1N1] in populations in Beijing and elucidate influencing factors. METHODS: In January 2010, a randomized serologic survey of pandemic influenza A (H1N1 2009) was carried out. Six districts that were randomly selected with a total of 4601 participants involved in the survey have their antibody level tested by hemagglutination inhibition assay. RESULTS: Among the 4601 participants, the overall seropositive rate for pandemic influenza A (H1N1 2009) antibodies was 31.7%. The seropositivity prevalence in participants who received the pandemic H1N1 vaccination was 60.9%. Only 53.1% of the pandemic influenza A (H1N1 2009) seropositive individuals who had not received the vaccination experienced respiratory tract infection symptoms. Multivariate logistic regression revealed that factors such as age, occupation, dwelling type, whether the participant's family included students in school, and the vaccination history with pandemic influenza A (H1N1 2009) were associated with antibody titers (p<0.05). CONCLUSIONS: Our data indicated that almost 30.0% of the residents had appropriate antibody titers against pandemic influenza A (H1N1 2009) in Beijing, and these titers may provide an immune barrier.
Authors: Anna J X Zhang; Kelvin K W To; Herman Tse; Kwok-Hung Chan; Kun-Yuan Guo; Can Li; Ivan F N Hung; Jasper F W Chan; Honglin Chen; Sidney Tam; Kwok-Yung Yuen Journal: Clin Vaccine Immunol Date: 2011-09-07
Authors: Camille Achonu; Laura Rosella; Jonathan B Gubbay; Shelley Deeks; Anu Rebbapragada; Tony Mazzulli; Don Willison; Julie Foisy; Allison McGeer; Ian Johnson; Marie LaFreniere; Caitlin Johnson; Jacqueline Willmore; Carmen Yue; Natasha S Crowcroft Journal: PLoS One Date: 2011-11-14 Impact factor: 3.240
Authors: Chad M Cox; Kate Goodin; Emily Fisher; Fatimah S Dawood; Janet J Hamilton; German F Leparc; Monica Gray; Linda Nelson; Rebekah H Borse; James A Singleton; Carrie Reed; Amanda L Balish; Jacqueline M Katz; Richard S Hopkins; Alicia M Fry Journal: PLoS One Date: 2011-12-20 Impact factor: 3.240