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Literature DB >> 21046984

Antihyperglycemic activity of compounds isolated from Indian medicinal plants.

Abstract

Eleven antidiabetic Indian medicinal plants were investigated in streptozotocin induced diabetic rat model and provided scientific validation to prove their antihyperglycemic activity. Antidiabetic principles from five plants were isolated. All the compounds isolated were evaluated for antihyperglycemic activity in streptozotocin induced diabetic rat model and activities were compared with standard drug metformin. Some compounds were also screened in db/db mice. Two compounds (PP-1 and PP-2) inhibited significantly the activity of PTPase-1B in an in vitro system. This might be the underlying mechanism of antihyperglycemic activity of these compounds.

Entities: Chemical Disease Gene Species

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Year: 2010 PMID： 21046984

Source DB: PubMed Journal: Indian J Exp Biol ISSN： 0019-5189 Impact factor: 0.818

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Cited

7 in total

1. Computer-aided drug design of Azadirachta indica compounds against nervous necrosis virus by targeting grouper heat shock cognate protein 70 (GHSC70): quantum mechanics calculations and molecular dynamic simulation approaches.

Authors: Sk Injamamul Islam; Saloa Saloa; Sarower Mahfuj; Md Jakiul Islam; Moslema Jahan Mou
Journal: Genomics Inform Date: 2022-09-30

2. Designing and screening of universal drug from neem (Azadirachta indica) and standard drug chemicals against influenza virus nucleoprotein.

Authors: Aftab Ahmad; Muhammad Rizwan Javed; Abdul Qayyum Rao; Tayyab Husnain
Journal: BMC Complement Altern Med Date: 2016-12-16 Impact factor: 3.659

3. Ameliorative Activity of Ethanol Extract of Artocarpus heterophyllus Stem Bark on Pancreatic β-Cell Dysfunction in Alloxan-Induced Diabetic Rats.

Authors: Basiru O Ajiboye; Oluwafemi A Ojo; Oluwatosin Adeyonu; Oluwatosin D Imiere; Adewale O Fadaka; Adetutu O Osukoya
Journal: J Evid Based Complementary Altern Med Date: 2016-12-30

Review 4. Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development.

Authors: Safaet Alam; Md Moklesur Rahman Sarker; Taposhi Nahid Sultana; Md Nafees Rahman Chowdhury; Mohammad A Rashid; Nusrat Islam Chaity; Chao Zhao; Jianbo Xiao; Elsayed E Hafez; Shah Alam Khan; Isa Naina Mohamed
Journal: Front Endocrinol (Lausanne) Date: 2022-02-24 Impact factor: 5.555

Antihyperglycemic activity of compounds isolated from Indian medicinal plants.

1. Computer-aided drug design of Azadirachta indica compounds against nervous necrosis virus by targeting grouper heat shock cognate protein 70 (GHSC70): quantum mechanics calculations and molecular dynamic simulation approaches.

2. Designing and screening of universal drug from neem (Azadirachta indica) and standard drug chemicals against influenza virus nucleoprotein.

3. Ameliorative Activity of Ethanol Extract of Artocarpus heterophyllus Stem Bark on Pancreatic β-Cell Dysfunction in Alloxan-Induced Diabetic Rats.

Review 4. Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development.

5. Development and Validation of an HPLC Method for Karanjin in Pongamia pinnata linn. Leaves.

6. Molecular docking based screening of neem-derived compounds with the NS1 protein of Influenza virus.

7. Screening and design of anti-diabetic compounds sourced from the leaves of neem (Azadirachta indica).