Literature DB >> 21046982

Amelioration of tamoxifen-induced liver injury in rats by grape seed extract, black seed extract and curcumin.

Hesham A El-Beshbishy1, Ahmed M Mohamadin, Ayman A Nagy, Ashraf B Abdel-Naim.   

Abstract

Liver injury was induced in female rats using tamoxifen (TAM). Grape seeds (Vitis vinifera) extract (GSE), black seed (Nigella sativa) extract (NSE), curcumin (CUR) or silymarin (SYL) were orally administered to TAM-intoxicated rats. Liver histopathology of TAM-intoxicated:rats showed pathological changes. TAM-intoxication elicited declines in liver antioxidant enzymes levels (glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase), reduced glutathione (GSH) and GSH/GSSG ratio plus the hepatic elevations in lipid peroxides, oxidized glutathione (GSSG), tumor necrosis factor-alpha (TNF-alpha) and serum liver enzymes; alanine transaminase, aspartate transaminase, alkaline phosphatase, lactate dehydrogenase and gamma glutamyl transferase levels. Oral intake of NSE, GSE, CUR or SYL to TAM-intoxicated rats, attenuated histopathological changes and corrected all parameters mentioned above. Improvements were prominent in case of NSE (similarly SYL) > CUR > GSE. Data indicated that NSE, GSE or CUR act as free radicals scavengers and protect TAM-induced liver injury in rats.

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Year:  2010        PMID： 21046982

Source DB:  PubMed          Journal:  Indian J Exp Biol        ISSN： 0019-5189            Impact factor:   0.818


  12 in total

1.  Hepatoprotective Activity of Methanolic Extract of Bauhinia purpurea Leaves against Paracetamol-Induced Hepatic Damage in Rats.

Authors:  F Yahya; S S Mamat; M F F Kamarolzaman; A A Seyedan; K F Jakius; N D Mahmood; M S Shahril; Z Suhaili; N Mohtarrudin; D Susanti; M N Somchit; L K Teh; M Z Salleh; Z A Zakaria
Journal:  Evid Based Complement Alternat Med       Date:  2013-06-18       Impact factor: 2.629

2.  Amelioration of paracetamol-induced hepatotoxicity in rat by the administration of methanol extract of Muntingia calabura L. leaves.

Authors:  N D Mahmood; S S Mamat; F H Kamisan; F Yahya; M F F Kamarolzaman; N Nasir; N Mohtarrudin; S F Md Tohid; Z A Zakaria
Journal:  Biomed Res Int       Date:  2014-04-24       Impact factor: 3.411

3.  Hepatoprotective and Antioxidant Potential of Organic and Conventional Grape Juices in Rats Fed a High-Fat Diet.

Authors:  Iselde Buchner; Niara Medeiros; Denise Dos Santos Lacerda; Carlos Augusto B M Normann; Tanise Gemelli; Paula Rigon; Clovis Milton Duval Wannmacher; João Antônio Pegas Henriques; Caroline Dani; Cláudia Funchal
Journal:  Antioxidants (Basel)       Date:  2014-04-30

4.  Methanol extract of Dicranopteris linearis L. leaves impedes acetaminophen-induced liver intoxication partly by enhancing the endogenous antioxidant system.

Authors:  Zainul Amiruddin Zakaria; Farah Hidayah Kamisan; Maizatul Hasyima Omar; Nur Diyana Mahmood; Fezah Othman; Siti Selina Abdul Hamid; Muhammad Nazrul Hakim Abdullah
Journal:  BMC Complement Altern Med       Date:  2017-05-18       Impact factor: 3.659

5.  IN VIVO CARBON TETRACHLORIDE-INDUCED HEPATOPROTECTIVE AND IN VITRO CYTOTOXIC ACTIVITIES OF GARCINIA HOMBRONIANA (SEASHORE MANGOSTEEN).

Authors:  Nargis Jamila; Naeem Khan; Amir Atlas Khan; Imran Khan; Sadiq Noor Khan; Zainal Amiruddin Zakaria; Melati Khairuddean; Hasnah Osman; Kyong Su Kim
Journal:  Afr J Tradit Complement Altern Med       Date:  2017-01-13

6.  Endogenous Antioxidant and LOX-Mediated Systems Contribute to the Hepatoprotective Activity of Aqueous Partition of Methanol Extract of Muntingia calabura L. Leaves against Paracetamol Intoxication.

Authors:  Zainul Amiruddin Zakaria; Nur Diyana Mahmood; Siti Syariah Mamat; Nurliana Nasir; Maizatul Hasyima Omar
Journal:  Front Pharmacol       Date:  2018-02-15       Impact factor: 5.810

7.  Hepatoprotective and antioxidant activities of Dicranopteris linearis leaf extract against paracetamol-induced liver intoxication in rats.

Authors:  Zainul Amiruddin Zakaria; Farah Hidayah Kamisan; Teh Lay Kek; Mohd Zaki Salleh
Journal:  Pharm Biol       Date:  2020-12       Impact factor: 3.503

8.  Effect of methanol extract of Dicranopteris linearis against carbon tetrachloride-induced acute liver injury in rats.

Authors:  Farah Hidayah Kamisan; Farhana Yahya; Siti Syariah Mamat; Mohamad Fauzi Fahmi Kamarolzaman; Norhafizah Mohtarrudin; Teh Lay Kek; Mohd Zaki Salleh; Mohd Khairi Hussain; Zainul Amiruddin Zakaria
Journal:  BMC Complement Altern Med       Date:  2014-04-04       Impact factor: 3.659

9.  Methanol extract of Melastoma malabathricum leaves exerted antioxidant and liver protective activity in rats.

Authors:  Siti Syariah Mamat; Mohamad Fauzi Fahmi Kamarolzaman; Farhana Yahya; Nur Diyana Mahmood; Muhammad Syahmi Shahril; Krystal Feredoline Jakius; Norhafizah Mohtarrudin; Siew Mooi Ching; Deny Susanti; Muhammad Taher; Zainul Amiruddin Zakaria
Journal:  BMC Complement Altern Med       Date:  2013-11-23       Impact factor: 3.659

10.  Hepatoprotective action of various partitions of methanol extract of Bauhinia purpurea leaves against paracetamol-induced liver toxicity: involvement of the antioxidant mechanisms.

Authors:  Zainul Amiruddin Zakaria; Farhana Yahya; Siti Syariah Mamat; Nur Diyana Mahmood; Nurhafizah Mohtarrudin; Muhammad Taher; Siti Selina Abdul Hamid; Lay Kek Teh; Mohd Zaki Salleh
Journal:  BMC Complement Altern Med       Date:  2016-06-11       Impact factor: 3.659
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