| Literature DB >> 21046414 |
Maria Pilar Bas Suárez1, Jezabel López Brito, Candelaria Santana Reyes, Manuel Gresa Muñoz, Rosario Diaz Pulido, Jose Carlos Lodos Rojas.
Abstract
Congenital leukemia is a rare disease with particular biological and clinical characteristics which differs from those of older children and adults. Here, we describe two cases of congenital acute lymphoblastic leukemia in two newborns with different clinical presentations (leukemia cutis vs. splenomegaly and respiratory distress) and fatal outcome. Both cases shared the expression of myeloid antigens (CD65) and cytogenetic disorders involving the MLL gene (location 11q23) which are associated to extremely poor prognosis.Entities:
Mesh:
Year: 2010 PMID: 21046414 DOI: 10.1007/s00431-010-1339-8
Source DB: PubMed Journal: Eur J Pediatr ISSN: 0340-6199 Impact factor: 3.183