| Literature DB >> 21046213 |
Lidia Ibáñez1, Maria José Alcaraz, Nuria Maicas, David Guede, José Ramón Caeiro, Marije I Koenders, Wim B van den Berg, Maria Luisa Ferrándiz.
Abstract
We have studied the influence of ovariectomy on the inflammatory response and bone metabolism on CIA as a model of postmenopausal arthritis as well as the effects of tin protoporphyrin IX (SnPP), a heme oxygenase inhibitor. Ovariectomy in non-arthritic mice produced increased serum PGD2 levels and up-regulated the expression of COX-2, h-PGDS, l-PGDS, and HO-1 in the joints. In CIA, ovariectomy potentiated the inflammatory response with higher levels of serum IL-6 and MMP-3, local PGD2 and MMP-3 as well as trabecular bone erosion. In OVX-CIA, SnPP decreased the serum levels of IL-6, MMP-3, and PGD2; down-regulated TNFα, COX-2, hPGDS, PGD2, PGE2, and MMP-3 in joint tissues; and also decreased focal bone loss in the inflamed joint. Ovariectomy up-regulates inflammatory mediators in non-arthritic and in arthritic animals. In the OVX-CIA model, SnPP exerts anti-inflammatory effects which are not associated with the prevention of systemic bone loss.Entities:
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Year: 2011 PMID： 21046213 DOI： 10.1007/s10753-010-9266-4
Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092