Literature DB >> 21045803

Bending the path to TOR.

Brian M Wiczer, Adem Kalender, George Thomas.   

Abstract

Cells sense and respond to physical stresses through mechanotransduction, a process that converts mechanical stimuli into biochemical signals. The bending of primary cilia has now been shown to modulate TOR signalling to negatively regulate cell size.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 21045803     DOI： 10.1038/ncb1110-1031

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  15 in total

1.  Primary cilia regulate mTORC1 activity and cell size through Lkb1.

Authors:  Christopher Boehlke; Fruzsina Kotsis; Vishal Patel; Simone Braeg; Henriette Voelker; Saskia Bredt; Theresa Beyer; Heike Janusch; Christoph Hamann; Markus Gödel; Klaus Müller; Martin Herbst; Miriam Hornung; Mara Doerken; Michael Köttgen; Roland Nitschke; Peter Igarashi; Gerd Walz; E Wolfgang Kuehn
Journal:  Nat Cell Biol       Date:  2010-10-24       Impact factor: 28.824

2.  mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.

Authors:  Ryan J O Dowling; Ivan Topisirovic; Tommy Alain; Michael Bidinosti; Bruno D Fonseca; Emmanuel Petroulakis; Xiaoshan Wang; Ola Larsson; Anand Selvaraj; Yi Liu; Sara C Kozma; George Thomas; Nahum Sonenberg
Journal:  Science       Date:  2010-05-28       Impact factor: 47.728

Review 3.  The primary cilium: a signalling centre during vertebrate development.

Authors:  Sarah C Goetz; Kathryn V Anderson
Journal:  Nat Rev Genet       Date:  2010-05       Impact factor: 53.242

Review 4.  Molecular mechanisms of protein and lipid targeting to ciliary membranes.

Authors:  Brian T Emmer; Danijela Maric; David M Engman
Journal:  J Cell Sci       Date:  2010-02-15       Impact factor: 5.285

5.  Drosophila S6 kinase: a regulator of cell size.

Authors:  J Montagne; M J Stewart; H Stocker; E Hafen; S C Kozma; G Thomas
Journal:  Science       Date:  1999-09-24       Impact factor: 47.728

Review 6.  Polycystins and primary cilia: primers for cell cycle progression.

Authors:  Jing Zhou
Journal:  Annu Rev Physiol       Date:  2009       Impact factor: 19.318

7.  AMPK phosphorylation of raptor mediates a metabolic checkpoint.

Authors:  Dana M Gwinn; David B Shackelford; Daniel F Egan; Maria M Mihaylova; Annabelle Mery; Debbie S Vasquez; Benjamin E Turk; Reuben J Shaw
Journal:  Mol Cell       Date:  2008-04-25       Impact factor: 17.970

8.  Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.

Authors:  Gianfranco Distefano; Manila Boca; Isaline Rowe; Claas Wodarczyk; Li Ma; Klaus B Piontek; Gregory G Germino; Pier Paolo Pandolfi; Alessandra Boletta
Journal:  Mol Cell Biol       Date:  2009-03-02       Impact factor: 4.272

9.  Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling.

Authors:  A B Hanker; N Mitin; R S Wilder; E P Henske; F Tamanoi; A D Cox; C J Der
Journal:  Oncogene       Date:  2009-10-19       Impact factor: 9.867

10.  The late endosome is essential for mTORC1 signaling.

Authors:  Rory J Flinn; Ying Yan; Sumanta Goswami; Peter J Parker; Jonathan M Backer
Journal:  Mol Biol Cell       Date:  2010-01-06       Impact factor: 4.138
View more
  1 in total

1.  Arterial cyclic stretch regulates Lamtor1 and promotes neointimal hyperplasia via circSlc8a1/miR-20a-5p axis in vein grafts.

Authors:  Ji-Ting Liu; Qing-Ping Yao; Yi Chen; Fan Lv; Ze Liu; Han Bao; Yue Han; Ming-Liang Zhang; Zong-Lai Jiang; Ying-Xin Qi
Journal:  Theranostics       Date:  2022-06-21       Impact factor: 11.600
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.