Literature DB >> 21045085

Heading in a new direction: drug permeability in breast cancer brain metastasis.

George W Sledge1.   

Abstract

Systemic therapies for breast cancer brain metastasis are largely unsuccessful. Mouse models of brain metastasis show significant heterogeneity in uptake of paclitaxel and doxorubicin, with average levels more than those seen in normal brain tissue, but significantly less than in metastases to other organs. ©2010 AACR.

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Year:  2010        PMID： 21045085     DOI： 10.1158/1078-0432.CCR-10-2502

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  6 in total

1.  Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases.

Authors:  Frits Thorsen; Brett Fite; Lisa M Mahakian; Jai W Seo; Shengping Qin; Victoria Harrison; Sarah Johnson; Elizabeth Ingham; Charles Caskey; Terje Sundstrøm; Thomas J Meade; Patrick N Harter; Kai Ove Skaftnesmo; Katherine W Ferrara
Journal:  J Control Release       Date:  2013-10-29       Impact factor: 9.776

Review 2.  Challenges of developing small-molecule kinase inhibitors for brain tumors and the need for emphasis on free drug levels.

Authors:  Timothy P Heffron
Journal:  Neuro Oncol       Date:  2018-02-19       Impact factor: 12.300

3.  Microenvironment determinants of brain metastasis.

Authors:  Chenyu Zhang; Dihua Yu
Journal:  Cell Biosci       Date:  2011-02-25       Impact factor: 7.133

4.  Cerebrospinal fluid penetration of targeted therapeutics in pediatric brain tumor patients.

Authors:  Armin Sebastian Guntner; Andreas Peyrl; Lisa Mayr; Bernhard Englinger; Walter Berger; Irene Slavc; Wolfgang Buchberger; Johannes Gojo
Journal:  Acta Neuropathol Commun       Date:  2020-06-03       Impact factor: 7.801

Review 5.  Origins of metastatic traits.

Authors:  Sakari Vanharanta; Joan Massagué
Journal:  Cancer Cell       Date:  2013-10-14       Impact factor: 31.743

Review 6.  Targeting Breast Cancer Metastasis.

Authors:  Xin Jin; Ping Mu
Journal:  Breast Cancer (Auckl)       Date:  2015-09-01
  6 in total

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