OBJECTIVE: To compare the efficacy of percutaneous vertebroplasty (PV) with conservative therapy for patients with acute vertebral compression fractures. DESIGN: Prospective, nonrandomized, comparison study. BACKGROUND: The efficacy of PV has not been well established because there have been few comparative studies with conservatively treated control groups. PATIENTS AND METHODS: Fifty-five consecutive patients (8 men and 47 women, age 47-94) with osteoporosis and symptomatic acute vertebral compression fractures were enrolled. thirty-two patients received pv, whereas 23 received conservative therapy. OUTCOME MEASURES: Changes in pain intensity, physical functioning, and pain medication requirement were evaluated. RESULTS: Both PV and conservative therapy provided pain reduction (P < 0.001), improvements in physical functioning (P < 0.001), and decreased medication (P < 0.001). Reductions in visual analogue pain scores were more significant in the vertebroplasty group at 1 (P < 0.001) and 4 weeks (P < 0.001) but not at 12 months. Improvements in physical functioning were significant at 1 (P < 0.001) and 4 weeks (P < 0.001). Medication requirements were lower in the vertebroplasty group at all three time points. CONCLUSIONS: Pain relief, physical functioning improvement, and medication requirement after vertebroplasty are immediately and significantly better when compared with conservative therapy. Wiley Periodicals, Inc.
OBJECTIVE: To compare the efficacy of percutaneous vertebroplasty (PV) with conservative therapy for patients with acute vertebral compression fractures. DESIGN: Prospective, nonrandomized, comparison study. BACKGROUND: The efficacy of PV has not been well established because there have been few comparative studies with conservatively treated control groups. PATIENTS AND METHODS: Fifty-five consecutive patients (8 men and 47 women, age 47-94) with osteoporosis and symptomatic acute vertebral compression fractures were enrolled. thirty-two patients received pv, whereas 23 received conservative therapy. OUTCOME MEASURES: Changes in pain intensity, physical functioning, and pain medication requirement were evaluated. RESULTS: Both PV and conservative therapy provided pain reduction (P < 0.001), improvements in physical functioning (P < 0.001), and decreased medication (P < 0.001). Reductions in visual analogue pain scores were more significant in the vertebroplasty group at 1 (P < 0.001) and 4 weeks (P < 0.001) but not at 12 months. Improvements in physical functioning were significant at 1 (P < 0.001) and 4 weeks (P < 0.001). Medication requirements were lower in the vertebroplasty group at all three time points. CONCLUSIONS:Pain relief, physical functioning improvement, and medication requirement after vertebroplasty are immediately and significantly better when compared with conservative therapy. Wiley Periodicals, Inc.
Authors: Roberto Luigi Cazzato; Teodora Bellone; Marco Scardapane; Pierre De Marini; Pierre-Alexis Autrusseau; Pierre Auloge; Julien Garnon; Jack W Jennings; Afshin Gangi Journal: Eur Radiol Date: 2021-04-26 Impact factor: 5.315
Authors: S L Han; S L Wan; Q T Li; D T Xu; H M Zang; N J Chen; L Y Chen; W P Zhang; C Luan; F Yang; Z W Xu Journal: Osteoporos Int Date: 2014-08-23 Impact factor: 4.507