| Literature DB >> 21043512 |
Ian Paterson1, Lisa J Gibson, S B Jennifer Kan.
Abstract
An advanced C15-C35 subunit of the chivosazole polyene macrolides was prepared in a convergent manner, exploiting boron-mediated aldol reactions for the stereocontrolled construction of the C15-C26 and C27-C35 segments, followed by their Pd/Cu-promoted Stille coupling to configure the signature (23E,25E,27Z)-triene motif. Correlation with a known C28-C35 degradation fragment of chivosazole A was also achieved.Entities:
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Year: 2010 PMID： 21043512 DOI： 10.1021/ol102425n
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005