Literature DB >> 21043475

Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense.

Wei Wang1, Yi Han Zeng, Khadijo Osman, Kamlesh Shinde, Mukhlesur Rahman, Simon Gibbons, Qing Mu.   

Abstract

Two new norlignans, hyperiones A (1) and B (2), three new acylphloroglucinols, aspidinol C (3) and hyperaspidinols A (5) and B (6), the known compound aspidinol D (4), and the symmetrical dimeric xanthone hyperidixanthone (7) were isolated from Hypericum chinense. Their structures were established by spectroscopic analysis. In an antibacterial assay using a panel of multidrug-resistant (MDR) strains, compounds 3 and 4 exhibited promising activity against the NorA efflux protein overexpressing MDR Staphylococcus aureus strain SA-1199B with a minimum inhibitory concentration (MIC) of 2 μg/mL (8.4 μM) and 4 μg/mL (16.8 μM), respectively. The positive control antibiotic norfloxacin showed activity at MIC 32 μg/mL (100 μM).

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Year:  2010        PMID： 21043475     DOI： 10.1021/np1004483

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

1.  Methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and Enterococcus faecium active dimeric isobutyrylphloroglucinol from Ivesia gordonii.

Authors:  Marwa H Ahmed; Mohamed Ali Ibrahim; Jin Zhang; Farouk R Melek; Seham S El-Hawary; Melissa R Jacob; Ilias Muhammad
Journal:  Nat Prod Commun       Date:  2014-02       Impact factor: 0.986

2.  Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics.

Authors:  Cassandra L Quave; Miriam Estévez-Carmona; Cesar M Compadre; Gerren Hobby; Howard Hendrickson; Karen E Beenken; Mark S Smeltzer
Journal:  PLoS One       Date:  2012-01-05       Impact factor: 3.240

3.  Synthesis of the furo[2,3-b]chromene ring system of hyperaspindols A and B.

Authors:  Danielle L Paterson; David Barker
Journal:  Beilstein J Org Chem       Date:  2015-02-17       Impact factor: 2.883

4.  A Short and Efficient Total Synthesis of Ficuseptamines A and B.

Authors:  Hani Mutlak A Hassan
Journal:  Molecules       Date:  2018-07-26       Impact factor: 4.411

5.  Anti-Infectivity against Herpes Simplex Virus and Selected Microbes and Anti-Inflammatory Activities of Compounds Isolated from Eucalyptus globulus Labill.

Authors:  Viliam Brezáni; Veronika Leláková; Sherif T S Hassan; Kateřina Berchová-Bímová; Pavel Nový; Pavel Klouček; Petr Maršík; Stefano Dall'Acqua; Jan Hošek; Karel Šmejkal
Journal:  Viruses       Date:  2018-07-06       Impact factor: 5.048

Review 6.  Breaking down the cell wall: Still an attractive antibacterial strategy.

Authors:  Jingxuan Zhou; Yi Cai; Ying Liu; Haoyue An; Kaihong Deng; Muhammad Awais Ashraf; Lili Zou; Jun Wang
Journal:  Front Microbiol       Date:  2022-09-23       Impact factor: 6.064

7.  Cu-catalyzed hydroxycyclopropanol ring-opening cyclization to tetrahydrofurans and tetrahydropyrans: short total syntheses of hyperiones.

Authors:  Weida Liang; Xinpei Cai; Mingji Dai
Journal:  Chem Sci       Date:  2020-11-20       Impact factor: 9.825

Review 8.  Nor-Lignans: Occurrence in Plants and Biological Activities-A Review.

Authors:  Claudio Frezza; Alessandro Venditti; Chiara Toniolo; Daniela De Vita; Marco Franceschin; Antonio Ventrone; Lamberto Tomassini; Sebastiano Foddai; Marcella Guiso; Marcello Nicoletti; Mauro Serafini; Armandodoriano Bianco
Journal:  Molecules       Date:  2020-01-03       Impact factor: 4.411
  8 in total

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