Ying He1, Kai-Xuan Yang, Fan Yang, Xiu-Li Wu. 1. Department of Pathology, West China Second Hospital of Sichuan University, Chengdu, People's Republic of China.
Abstract
BACKGROUND: Solitary fibrous tumor (SFT) of the female genital tract is an extremely rare neoplasm of mesenchymal origin. CASE: A case of primary SFT originated from the vulva of a 39-year-old woman. The tumor presented as a 10-cm, well-circumscribed lump and was composed of bland-looking cells admixed with thin and thick collagen fibers with the appearance of hemangiopericytoma. Immunohistochemically, the spindle cells were strongly positive for CD99 and vimentin, with focal positivity for CD34, and were negative for S100, SMA, desmin, ER, PR, etc. Microscopic evaluation and immunohistochemistry supported the diagnosis of a primary benign vulvar SFT. The patient remained well 10 months after excision. CONCLUSION: To the best of our knowledge, this report is the first Chinese case of vulvar SFT in the English-language literature. SFT should be taken into consideration during the diagnostic process with spindle cell lesions of the vulva. The outcome of this tumor is based mostly on complete surgical resection.
BACKGROUND: Solitary fibrous tumor (SFT) of the female genital tract is an extremely rare neoplasm of mesenchymal origin. CASE: A case of primary SFT originated from the vulva of a 39-year-old woman. The tumor presented as a 10-cm, well-circumscribed lump and was composed of bland-looking cells admixed with thin and thick collagen fibers with the appearance of hemangiopericytoma. Immunohistochemically, the spindle cells were strongly positive for CD99 and vimentin, with focal positivity for CD34, and were negative for S100, SMA, desmin, ER, PR, etc. Microscopic evaluation and immunohistochemistry supported the diagnosis of a primary benign vulvar SFT. The patient remained well 10 months after excision. CONCLUSION: To the best of our knowledge, this report is the first Chinese case of vulvar SFT in the English-language literature. SFT should be taken into consideration during the diagnostic process with spindle cell lesions of the vulva. The outcome of this tumor is based mostly on complete surgical resection.