BACKGROUND: Although tissue adhesives and traditional sutures were compared in numerous studies during the early stages of healing, it has to be clarified, from the histological and biomechanical point of view, how the differences develop during the later phases. METHODS: Twenty-four male Sprague-Dawley rats were used and divided into 2 groups: the IRS (intradermal running suture) and G (glue) groups. Two parallel full-thickness skin incisions were made on the back of each rat. Wounds in the IRS group were closed by an IRS, whereas wounds in the G group were closed using tissue adhesive (n-butylcyanoacrylate). Rats were sacrificed 7 and 22 days after surgery. RESULTS: Similar wound tensile strengths of glued and sutured wounds were measured on days 7 (IRS = 10.3 ± 1.7 g/mm(2) vs. G = 12.9 ± 4.0 g/mm(2), p = 0.9612) and 22 (IRS = 95.6 ± 15.7 g/mm(2) vs. G = 85.6 ± 16.4 g/mm(2), p = 0.2502) after surgery. Histology revealed a significantly increased amount of granulation tissue formation in glued wounds on day 7. The difference in granulation tissue formation was reduced until day 22. CONCLUSIONS: Tissue adhesive based on n-butylcyanoacrylate presents a fair alternative to traditional suture wound closure techniques.
BACKGROUND: Although tissue adhesives and traditional sutures were compared in numerous studies during the early stages of healing, it has to be clarified, from the histological and biomechanical point of view, how the differences develop during the later phases. METHODS: Twenty-four male Sprague-Dawley rats were used and divided into 2 groups: the IRS (intradermal running suture) and G (glue) groups. Two parallel full-thickness skin incisions were made on the back of each rat. Wounds in the IRS group were closed by an IRS, whereas wounds in the G group were closed using tissue adhesive (n-butylcyanoacrylate). Rats were sacrificed 7 and 22 days after surgery. RESULTS: Similar wound tensile strengths of glued and sutured wounds were measured on days 7 (IRS = 10.3 ± 1.7 g/mm(2) vs. G = 12.9 ± 4.0 g/mm(2), p = 0.9612) and 22 (IRS = 95.6 ± 15.7 g/mm(2) vs. G = 85.6 ± 16.4 g/mm(2), p = 0.2502) after surgery. Histology revealed a significantly increased amount of granulation tissue formation in glued wounds on day 7. The difference in granulation tissue formation was reduced until day 22. CONCLUSIONS: Tissue adhesive based on n-butylcyanoacrylate presents a fair alternative to traditional suture wound closure techniques.
Authors: Tomáš Vasilenko; Ivan Kováč; Martin Slezák; Ján Ďurkáč; Vlasta Peržel'ová; Matúš Čoma; Miriam Kaňuchová; Lukáš Urban; Pavol Szabo; Barbora Dvořánková; Andrej Vrzgula; Robert Zajíček; Karel Smetana; Peter Gál Journal: In Vivo Date: 2022 May-Jun Impact factor: 2.406
Authors: Peter Gál; Tomáš Vasilenko; Ivan Kováč; Matúš Čoma; Ján Jakubčo; Martina Jakubčová; Vlasta Peržeľová; Lukáš Urban; Michal Kolář; František Sabol; Ján Luczy; Martin Novotný; Jaroslav Majerník; Hans-Joachim Gabius; Karel Jr Smetana Journal: Mol Med Rep Date: 2020-12-10 Impact factor: 2.952
Authors: Mehmet Murat Bala; Abdullah Alper Şahin; Mehmet Boz; Yasin Durukan; Tülin Fırat; Murat Pakdil; Kutay Engin Özturan Journal: Med Sci Monit Date: 2021-09-06