E Attwa1, E Swelam. 1. Department of Dermatology & Venereology Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt. drenayatattwa@yahoo.com
Abstract
BACKGROUND: Psoriasis is a chronic and recurrent inflammatory skin disease, known as an oxidative stress condition. Smoking augments the risk of development of psoriasis. Although the relative importance of potential mechanisms of smoking-induced psoriasis is unknown, direct delivery of oxidants has been implicated in the pathogenesis of smoking-induced psoriasis. OBJECTIVES: This study aimed to investigate the smoking-induced oxidative stress in psoriatic patients and its correlation with the severity of the disease. METHODS: The levels of malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in 25 psoriatic patients (10 smokers, 10 non-smokers and 5 ex-smokers) and 20 healthy control subjects (10 smokers and 10 non-smokers). Clinical severity of psoriasis was determined according to the Psoriasis Area Severity Index (PASI) score. RESULTS: Our results showed a significant increase in serum MDA and decrease in the blood SOD levels in psoriatic patients compared with those in control subjects and those in smokers compared with those in non-smokers. The concentrations of MDA and SOD were significantly correlated with PASI score. There was a significant increase in PASI score in smoker patients compared with that in non-smokers and it increased with increasing the pack-years of smoking. CONCLUSIONS: Our results indicate that smoking-induced oxidative damage resulting from increased reactive oxygen species production along with insufficient capacity of antioxidant mechanisms may be involved in the pathogenesis of psoriasis.
BACKGROUND:Psoriasis is a chronic and recurrent inflammatory skin disease, known as an oxidative stress condition. Smoking augments the risk of development of psoriasis. Although the relative importance of potential mechanisms of smoking-induced psoriasis is unknown, direct delivery of oxidants has been implicated in the pathogenesis of smoking-induced psoriasis. OBJECTIVES: This study aimed to investigate the smoking-induced oxidative stress in psoriaticpatients and its correlation with the severity of the disease. METHODS: The levels of malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in 25 psoriaticpatients (10 smokers, 10 non-smokers and 5 ex-smokers) and 20 healthy control subjects (10 smokers and 10 non-smokers). Clinical severity of psoriasis was determined according to the Psoriasis Area Severity Index (PASI) score. RESULTS: Our results showed a significant increase in serum MDA and decrease in the blood SOD levels in psoriaticpatients compared with those in control subjects and those in smokers compared with those in non-smokers. The concentrations of MDA and SOD were significantly correlated with PASI score. There was a significant increase in PASI score in smoker patients compared with that in non-smokers and it increased with increasing the pack-years of smoking. CONCLUSIONS: Our results indicate that smoking-induced oxidative damage resulting from increased reactive oxygen species production along with insufficient capacity of antioxidant mechanisms may be involved in the pathogenesis of psoriasis.
Authors: M Severs; S J H van Erp; M E van der Valk; M J J Mangen; H H Fidder; M van der Have; A A van Bodegraven; D J de Jong; C J van der Woude; M J L Romberg-Camps; C H M Clemens; J M Jansen; P C van de Meeberg; N Mahmmod; C Y Ponsioen; C Bolwerk; J R Vermeijden; M J Pierik; P D Siersema; M Leenders; A E van der Meulen-de Jong; G Dijkstra; B Oldenburg Journal: J Crohns Colitis Date: 2015-12-30 Impact factor: 9.071