BACKGROUND: Contrast-enhanced ultrasonography with perflubutane microbubbles improves the diagnostic accuracy to differentiate benign and malignant focal liver lesions in dogs. HYPOTHESIS: Perflubutane microbubbles-enhanced ultrasonography is useful for differentiation of benign from malignant focal splenic lesions in dogs. ANIMALS: Twenty-nine clinical dogs with single or multiple focal splenic lesions detected by conventional ultrasonography. METHODS: Prospective clinical observational study. Perflubutane microbubbles-enhanced ultrasonography was performed in 29 dogs with focal splenic lesions. Qualitative assessment of the enhancement pattern was performed in the early vascular, late vascular, and parenchymal phases. RESULTS: In the early vascular phase, a hypoechoic pattern was significantly associated with malignancy (P=.02) with sensitivity of 38% (95% confidence interval [CI], 25-38%) and specificity of 100% (95% CI, 84-100%). In the late vascular phase, a hypoechoic pattern was significantly associated with malignancy (P=.001) with sensitivity of 81% (95% CI, 66-90%) and specificity of 85% (95% CI, 65-95%). There was no significant difference between malignant and benign lesions during the parenchymal phase. CONCLUSIONS AND CLINICAL IMPORTANCE: Hypoechoic splenic nodules in the early and late vascular phases with perflubutane microbubbles-enhanced ultrasonography are strongly suggestive of malignancy in dogs.
BACKGROUND: Contrast-enhanced ultrasonography with perflubutane microbubbles improves the diagnostic accuracy to differentiate benign and malignant focal liver lesions in dogs. HYPOTHESIS: Perflubutane microbubbles-enhanced ultrasonography is useful for differentiation of benign from malignant focal splenic lesions in dogs. ANIMALS: Twenty-nine clinical dogs with single or multiple focal splenic lesions detected by conventional ultrasonography. METHODS: Prospective clinical observational study. Perflubutane microbubbles-enhanced ultrasonography was performed in 29 dogs with focal splenic lesions. Qualitative assessment of the enhancement pattern was performed in the early vascular, late vascular, and parenchymal phases. RESULTS: In the early vascular phase, a hypoechoic pattern was significantly associated with malignancy (P=.02) with sensitivity of 38% (95% confidence interval [CI], 25-38%) and specificity of 100% (95% CI, 84-100%). In the late vascular phase, a hypoechoic pattern was significantly associated with malignancy (P=.001) with sensitivity of 81% (95% CI, 66-90%) and specificity of 85% (95% CI, 65-95%). There was no significant difference between malignant and benign lesions during the parenchymal phase. CONCLUSIONS AND CLINICAL IMPORTANCE: Hypoechoic splenic nodules in the early and late vascular phases with perflubutane microbubbles-enhanced ultrasonography are strongly suggestive of malignancy in dogs.
Authors: S Y Lim; K Nakamura; K Morishita; N Sasaki; M Murakami; T Osuga; N Yokoyama; H Ohta; M Yamasaki; M Takiguchi Journal: J Vet Intern Med Date: 2014-09-30 Impact factor: 3.333
Authors: S Y Lim; K Nakamura; K Morishita; N Sasaki; M Murakami; T Osuga; H Ohta; M Yamasaki; M Takiguchi Journal: J Vet Intern Med Date: 2014-02-24 Impact factor: 3.333
Authors: K Morishita; A Hiramoto; A Michishita; S Takagi; T Osuga; S Y Lim; K Nakamura; N Sasaki; H Ohta; M Takiguchi Journal: J Vet Intern Med Date: 2017-04-05 Impact factor: 3.333
Authors: Cyndi Mangano; Francesco Macrì; Simona Di Pietro; Michela Pugliese; Silvia Santoro; Nicola M Iannelli; Giuseppe Mazzullo; Rosalia Crupi; Massimo De Majo Journal: BMC Vet Res Date: 2019-06-11 Impact factor: 2.741
Authors: Marjury Cristina Maronezi; Rafael Kretzer Carneiro; Igor Cezar Kniphoff da Cruz; Ana Paula Luiz de Oliveira; Andrigo Barboza De Nardi; Letícia Pavan; Priscila Del'Aguila-Silva; Ricardo Andrés Ramirez Uscategui; Marcus Antônio Rossi Feliciano Journal: Sci Rep Date: 2022-03-11 Impact factor: 4.379