Literature DB >> 21038041

Structure-based design of selective high-affinity telomeric quadruplex-binding ligands.

Caterina Maria Lombardo1, Iria Sánchez Martínez, Shozeb Haider, Valérie Gabelica, Edwin De Pauw, John E Moses, Stephen Neidle.   

Abstract

A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.

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Year:  2010        PMID： 21038041     DOI： 10.1039/c0cc02917c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  11 in total

1.  Designed compounds for recognition of 10 base pairs of DNA with two at binding sites.

Authors:  Yang Liu; Yun Chai; Arvind Kumar; Richard R Tidwell; David W Boykin; W David Wilson
Journal:  J Am Chem Soc       Date:  2012-03-09       Impact factor: 15.419

Review 2.  Tailored therapeutics based on 1,2,3-1H-triazoles: a mini review.

Authors:  Parteek Prasher; Mousmee Sharma
Journal:  Medchemcomm       Date:  2019-05-14       Impact factor: 3.597

3.  A new cationic porphyrin derivative (TMPipEOPP) with large side arm substituents: a highly selective G-quadruplex optical probe.

Authors:  Li-Na Zhu; Shu-Juan Zhao; Bin Wu; Xiao-Zeng Li; De-Ming Kong
Journal:  PLoS One       Date:  2012-05-22       Impact factor: 3.240

4.  Discovery of human TyrRS inhibitors by structure-based virtual screening, structural optimization, and bioassays.

Authors:  Shenzhen Huang; Xiang Wang; Guifeng Lin; Jie Cheng; Xiuli Chen; Weining Sun; Rong Xiang; Yamei Yu; Linli Li; Shengyong Yang
Journal:  RSC Adv       Date:  2019-03-22       Impact factor: 4.036

5.  KRAS Promoter G-Quadruplexes from Sequences of Different Length: A Physicochemical Study.

Authors:  Federica D'Aria; Bruno Pagano; Luigi Petraccone; Concetta Giancola
Journal:  Int J Mol Sci       Date:  2021-01-05       Impact factor: 5.923

6.  Combining Electrospray Mass Spectrometry (ESI-MS) and Computational Techniques in the Assessment of G-Quadruplex Ligands: A Hybrid Approach to Optimize Hit Discovery.

Authors:  Giovanni Ribaudo; Alberto Ongaro; Erika Oselladore; Maurizio Memo; Alessandra Gianoncelli
Journal:  J Med Chem       Date:  2021-09-12       Impact factor: 7.446

7.  Rational design of small-molecules to recognize G-quadruplexes of c-MYC promoter and telomere and the evaluation of their in vivo antitumor activity against breast cancer.

Authors:  Wei Long; Bo-Xin Zheng; Ying Li; Xuan-He Huang; Dan-Min Lin; Cui-Cui Chen; Jin-Qiang Hou; Tian-Miao Ou; Wing-Leung Wong; Kun Zhang; Yu-Jing Lu
Journal:  Nucleic Acids Res       Date:  2022-02-28       Impact factor: 16.971

8.  Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry.

Authors:  Marco Di Antonio; Giulia Biffi; Angelica Mariani; Eun-Ang Raiber; Raphaël Rodriguez; Shankar Balasubramanian
Journal:  Angew Chem Int Ed Engl       Date:  2012-10-04       Impact factor: 15.336

9.  Phenyl 1,2,3-triazole-thymidine ligands stabilize G-quadruplex DNA, inhibit DNA synthesis and potentially reduce tumor cell proliferation over 3'-azido deoxythymidine.

Authors:  Jerald Mahesh Kumar; Mohammed M Idris; Gunda Srinivas; Pallerla Vinay Kumar; Vuppalapaty Meghah; Mitta Kavitha; Chada Raji Reddy; Prathama S Mainkar; Biswajit Pal; Srivari Chandrasekar; Narayana Nagesh
Journal:  PLoS One       Date:  2013-08-19       Impact factor: 3.240

10.  Understanding mixed sequence DNA recognition by novel designed compounds: the kinetic and thermodynamic behavior of azabenzimidazole diamidines.

Authors:  Ananya Paul; Yun Chai; David W Boykin; W David Wilson
Journal:  Biochemistry       Date:  2014-12-24       Impact factor: 3.162
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