BACKGROUND: The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia. OBJECTIVE: To replicate this association in an independent population with a different genetic background. METHODS: The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland. RESULTS: It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p=7.35 × 10(-5)) and with a comparable effect size with MS (OR=1.31, 95% CI 1.14 to 1.52). CONCLUSION: These data provide further evidence of the association of MS disease with variation within CBLB.
BACKGROUND: The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia. OBJECTIVE: To replicate this association in an independent population with a different genetic background. METHODS: The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland. RESULTS: It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p=7.35 × 10(-5)) and with a comparable effect size with MS (OR=1.31, 95% CI 1.14 to 1.52). CONCLUSION: These data provide further evidence of the association of MS disease with variation within CBLB.
Authors: Antonio Alcina; Maria Fedetz; Oscar Fernández; Albert Saiz; Guillermo Izquierdo; Miguel Lucas; Laura Leyva; Juan-Antonio García-León; María Del Mar Abad-Grau; Iraide Alloza; Alfredo Antigüedad; María J Garcia-Barcina; Koen Vandenbroeck; Jezabel Varadé; Belén de la Hera; Rafael Arroyo; Manuel Comabella; Xavier Montalban; Natalia Petit-Marty; Arcadi Navarro; David Otaegui; Javier Olascoaga; Yolanda Blanco; Elena Urcelay; Fuencisla Matesanz Journal: J Med Genet Date: 2012-11-17 Impact factor: 6.318
Authors: D Jafari; M J Mousavi; S Keshavarz Shahbaz; L Jafarzadeh; S Tahmasebi; J Spoor; A Esmaeilzadeh Journal: Clin Exp Immunol Date: 2021-01-10 Impact factor: 5.732
Authors: Sebastian Peer; Giuseppe Cappellano; Natascha Hermann-Kleiter; Karin Albrecht-Schgoer; Reinhard Hinterleitner; Gottfried Baier; Thomas Gruber Journal: Front Immunol Date: 2018-10-08 Impact factor: 7.561