Literature DB >> 21036998

Pseudomonas aeruginosa MucD regulates the alginate pathway through activation of MucA degradation via MucP proteolytic activity.

F Heath Damron1, Hongwei D Yu.   

Abstract

Alginate overproduction in Pseudomonas aeruginosa can be caused by the proteolysis of the anti-sigma factor MucA regulated by the AlgW protease. Here, we show that inactivation of MucD, an HtrA/DegP homolog and alginate regulator, can bypass AlgW, leading to an atypical proteolysis of MucA that is dependent on the MucP protease.

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Year:  2010        PMID： 21036998      PMCID： PMC3019965          DOI： 10.1128/JB.01132-10

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  21 in total

1.  Independent regulation of MucD, an HtrA-like protease in Pseudomonas aeruginosa, and the role of its proteolytic motif in alginate gene regulation.

Authors:  Lynn F Wood; Dennis E Ohman
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

2.  New method for quantitative determination of uronic acids.

Authors:  N Blumenkrantz; G Asboe-Hansen
Journal:  Anal Biochem       Date:  1973-08       Impact factor: 3.365

3.  Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections.

Authors:  M J Preston; P C Seed; D S Toder; B H Iglewski; D E Ohman; J K Gustin; J B Goldberg; G B Pier
Journal:  Infect Immun       Date:  1997-08       Impact factor: 3.441

4.  Cell wall-inhibitory antibiotics activate the alginate biosynthesis operon in Pseudomonas aeruginosa: Roles of sigma (AlgT) and the AlgW and Prc proteases.

Authors:  Lynn F Wood; Andrew J Leech; Dennis E Ohman
Journal:  Mol Microbiol       Date:  2006-10       Impact factor: 3.501

5.  Multiple promoters and induction by heat shock of the gene encoding the alternative sigma factor AlgU (sigma E) which controls mucoidy in cystic fibrosis isolates of Pseudomonas aeruginosa.

Authors:  M J Schurr; H Yu; J C Boucher; N S Hibler; V Deretic
Journal:  J Bacteriol       Date:  1995-10       Impact factor: 3.490

6.  Measurement of uronic acids without interference from neutral sugars.

Authors:  T M Filisetti-Cozzi; N C Carpita
Journal:  Anal Biochem       Date:  1991-08-15       Impact factor: 3.365

Review 7.  Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia.

Authors:  J R Govan; V Deretic
Journal:  Microbiol Rev       Date:  1996-09

8.  Transcriptional analysis of the Pseudomonas aeruginosa genes algR, algB, and algD reveals a hierarchy of alginate gene expression which is modulated by algT.

Authors:  D J Wozniak; D E Ohman
Journal:  J Bacteriol       Date:  1994-10       Impact factor: 3.490

9.  Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtrA.

Authors:  J C Boucher; J Martinez-Salazar; M J Schurr; M H Mudd; H Yu; V Deretic
Journal:  J Bacteriol       Date:  1996-01       Impact factor: 3.490

10.  Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patients.

Authors:  D W Martin; M J Schurr; M H Mudd; J R Govan; B W Holloway; V Deretic
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-15       Impact factor: 11.205
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  24 in total

1.  Vanadate and triclosan synergistically induce alginate production by Pseudomonas aeruginosa strain PAO1.

Authors:  F Heath Damron; Michael R Davis; T Ryan Withers; Robert K Ernst; Joanna B Goldberg; Guangli Yu; Hongwei D Yu
Journal:  Mol Microbiol       Date:  2011-06-16       Impact factor: 3.501

2.  Ethanol Stimulates Trehalose Production through a SpoT-DksA-AlgU-Dependent Pathway in Pseudomonas aeruginosa.

Authors:  Colleen E Harty; Dorival Martins; Georgia Doing; Dallas L Mould; Michelle E Clay; Patricia Occhipinti; Dao Nguyen; Deborah A Hogan
Journal:  J Bacteriol       Date:  2019-05-22       Impact factor: 3.490

Review 3.  Regulation of bacterial virulence gene expression by cell envelope stress responses.

Authors:  Josué Flores-Kim; Andrew J Darwin
Journal:  Virulence       Date:  2014       Impact factor: 5.882

4.  Modulation of Pertussis and Adenylate Cyclase Toxins by Sigma Factor RpoE in Bordetella pertussis.

Authors:  Mariette Barbier; Dylan T Boehm; Emel Sen-Kilic; Claire Bonnin; Theo Pinheiro; Casey Hoffman; Mary Gray; Erik Hewlett; F Heath Damron
Journal:  Infect Immun       Date:  2016-12-29       Impact factor: 3.441

Review 5.  Bacterial Extracellular Polysaccharides in Biofilm Formation and Function.

Authors:  Dominique H Limoli; Christopher J Jones; Daniel J Wozniak
Journal:  Microbiol Spectr       Date:  2015-06

6.  Dual positive feedback regulation of protein degradation of an extra-cytoplasmic function σ factor for cell differentiation in Streptomyces coelicolor.

Authors:  Xu-Ming Mao; Ning Sun; Feng Wang; Shuai Luo; Zhan Zhou; Wei-Hong Feng; Fang-Liang Huang; Yong-Quan Li
Journal:  J Biol Chem       Date:  2013-09-06       Impact factor: 5.157

7.  Proteomic analysis of Vibrio cholerae outer membrane vesicles.

Authors:  Emrah Altindis; Yang Fu; John J Mekalanos
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-31       Impact factor: 11.205

8.  Analysis of the Pseudomonas aeruginosa regulon controlled by the sensor kinase KinB and sigma factor RpoN.

Authors:  F Heath Damron; Joshua P Owings; Yuta Okkotsu; John J Varga; Jill R Schurr; Joanna B Goldberg; Michael J Schurr; Hongwei D Yu
Journal:  J Bacteriol       Date:  2011-12-30       Impact factor: 3.490

Review 9.  Function of site-2 proteases in bacteria and bacterial pathogens.

Authors:  Jessica S Schneider; Michael S Glickman
Journal:  Biochim Biophys Acta       Date:  2013-12

10.  Overproduction of the AlgT Sigma Factor Is Lethal to Mucoid Pseudomonas aeruginosa.

Authors:  Ashley R Cross; Vishnu Raghuram; Zihuan Wang; Debayan Dey; Joanna B Goldberg
Journal:  J Bacteriol       Date:  2020-09-23       Impact factor: 3.490
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