BACKGROUND: Expression of ligands of natural killer group 2D (NKG2D) immunoreceptors, such as major histocompatibility complex class I-related chain A/B (MICA/B), has been proposed to play an important role in tumour immunosurveillance. Soluble forms of MICA/B are increased in sera of cancer patients and are postulated to impair antitumour immune response by downregulating expression of NKG2D immunoreceptors. Serum levels of soluble MICA have been shown to be of diagnostic significance in malignant diseases. AIMS: The potential of soluble MICB (sMICB) as a marker for oral squamous cell carcinoma (OSCC) was investigated. RESULTS: sMICB levels did not differ significantly from those in normal control individuals. However, the findings indicate that sMICB levels are significantly increased in stage IV OSCC and high sMICB levels are significantly associated with decreased survival rates in patients.
BACKGROUND: Expression of ligands of natural killer group 2D (NKG2D) immunoreceptors, such as major histocompatibility complex class I-related chain A/B (MICA/B), has been proposed to play an important role in tumour immunosurveillance. Soluble forms of MICA/B are increased in sera of cancerpatients and are postulated to impair antitumour immune response by downregulating expression of NKG2D immunoreceptors. Serum levels of soluble MICA have been shown to be of diagnostic significance in malignant diseases. AIMS: The potential of soluble MICB (sMICB) as a marker for oral squamous cell carcinoma (OSCC) was investigated. RESULTS:sMICB levels did not differ significantly from those in normal control individuals. However, the findings indicate that sMICB levels are significantly increased in stage IV OSCC and high sMICB levels are significantly associated with decreased survival rates in patients.
Authors: Gang Liu; Shengjun Lu; Xuanjun Wang; Stephanie T Page; Celestia S Higano; Stephen R Plymate; Norman M Greenberg; Shaoli Sun; Zihai Li; Jennifer D Wu Journal: J Clin Invest Date: 2013-09-09 Impact factor: 14.808
Authors: Hoang Van Tong; Le Huu Song; Nghiem Xuan Hoan; Bui Khac Cuong; Bui Tien Sy; Ho Anh Son; Do Quyet; Vu Quoc Binh; Peter G Kremsner; Claus Thomas Bock; Thirumalaisamy P Velavan; Nguyen Linh Toan Journal: BMC Infect Dis Date: 2015-01-23 Impact factor: 3.090
Authors: Stephan Klöss; Nicole Chambron; Tanja Gardlowski; Sandra Weil; Joachim Koch; Ruth Esser; Elke Pogge von Strandmann; Michael A Morgan; Lubomir Arseniev; Oliver Seitz; Ulrike Köhl Journal: Front Immunol Date: 2015-11-02 Impact factor: 7.561