Literature DB >> 21035317

Synergistic effects of parthenolide and benznidazole on Trypanosoma cruzi.

Karin Juliane Pelizzaro-Rocha1, Tatiana Shioji Tiuman, Erika Izumi, Tânia Ueda-Nakamura, Benedito Prado Dias Filho, Celso Vataru Nakamura.   

Abstract

Parthenolide previously isolated from Tanacetum vulgare was tested for its in vitro combinatory effect with benznidazole against Trypanosoma cruzi. Parthenolide showed a strong synergistic activity against epimastigote forms, reducing 23-fold the concentration of benznidazole necessary to inhibit 50% of cell growth (IC(50) of 1.6 to 0.07 μg/ml) when in combination with parthenolide. In addition, an additive effect against trypomastigote forms (FIC 1.06), followed by an antagonistic effect on the cytotoxicity (FIC 2.36), was observed for the combination of both drugs. Parthenolide induced morphological alterations in the body shape of trypomastigote forms, causing rounding and shortening of the parasite and loss of integrity of the plasma membrane, as previously described by other workers.
Copyright © 2010 Elsevier GmbH. All rights reserved.

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Year:  2010        PMID： 21035317     DOI： 10.1016/j.phymed.2010.09.005

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  12 in total

1.  In vitro and in vivo trypanocidal synergistic activity of N-butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide associated with benznidazole.

Authors:  Rodrigo Hinojosa Valdez; Lilian Tatiani Düsman Tonin; Tânia Ueda-Nakamura; Sueli Oliveira Silva; Benedito Prado Dias Filho; Edilson Nobuyoshi Kaneshima; Sueli Fumie Yamada-Ogatta; Lucy Megumi Yamauchi; Maria Helena Sarragiotto; Celso Vataru Nakamura
Journal:  Antimicrob Agents Chemother       Date:  2011-10-28       Impact factor: 5.191

2.  Clomipramine and Benznidazole Act Synergistically and Ameliorate the Outcome of Experimental Chagas Disease.

Authors:  Mónica Cristina García; Nicolás Eric Ponce; Liliana Maria Sanmarco; Rubén Hilario Manzo; Alvaro Federico Jimenez-Kairuz; Maria Pilar Aoki
Journal:  Antimicrob Agents Chemother       Date:  2016-05-23       Impact factor: 5.191

3.  Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni.

Authors:  Cristiana Lalli; Alessandra Guidi; Nadia Gennari; Sergio Altamura; Alberto Bresciani; Giovina Ruberti
Journal:  PLoS Negl Trop Dis       Date:  2015-01-30

4.  Anthelmintic activity of crude extract and essential oil of Tanacetum vulgare (Asteraceae) against adult worms of Schistosoma mansoni.

Authors:  Loyana Silva Godinho; Lara Soares Aleixo de Carvalho; Clarissa Campos Barbosa de Castro; Mirna Meana Dias; Priscila de Faria Pinto; Antônio Eduardo Miller Crotti; Pedro Luiz Silva Pinto; Josué de Moraes; Ademar A Da Silva Filho
Journal:  ScientificWorldJournal       Date:  2014-02-02

5.  Flavonoids and Sesquiterpene Lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni Worms.

Authors:  Luísa Maria Silveira de Almeida; Lara Soares Aleixo de Carvalho; Matheus Coutinho Gazolla; Pedro Luiz Silva Pinto; Marcos Paulo Nascimento da Silva; Josué de Moraes; Ademar A Da Silva Filho
Journal:  Evid Based Complement Alternat Med       Date:  2016-11-17       Impact factor: 2.629

6.  Effects of (1E,4E)-2-Methyl-1,5-bis(4-nitrophenyl)penta-1,4-dien-3-one on Trypanosoma cruzi and Its Combinational Effect with Benznidazole, Ketoconazole, or Fluconazole.

Authors:  Francieli Peron; Danielle Lazarin-Bidóia; Zia Ud Din; Edson Rodrigues-Filho; Tânia Ueda-Nakamura; Sueli de Oliveira Silva; Celso Vataru Nakamura
Journal:  Biomed Res Int       Date:  2017-05-23       Impact factor: 3.411

7.  Synergistic Effect of Lupenone and Caryophyllene Oxide against Trypanosoma cruzi.

Authors:  Glendy Polanco-Hernández; Fabiola Escalante-Erosa; Karlina García-Sosa; María E Rosado; Eugenia Guzmán-Marín; Karla Y Acosta-Viana; Alberto Giménez-Turba; Efraín Salamanca; Luis M Peña-Rodríguez
Journal:  Evid Based Complement Alternat Med       Date:  2013-05-20       Impact factor: 2.629

8.  The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process.

Authors:  Vânia Cristina Desoti; Danielle Lazarin-Bidóia; Fabianne Martins Ribeiro; Solange Cardoso Martins; Jean Henrique da Silva Rodrigues; Tania Ueda-Nakamura; Celso Vataru Nakamura; Valdecir Farias Ximenes; Sueli de Oliveira Silva
Journal:  PLoS One       Date:  2015-12-07       Impact factor: 3.240

9.  A quinoxaline derivative as a potent chemotherapeutic agent, alone or in combination with benznidazole, against Trypanosoma cruzi.

Authors:  Jean Henrique da Silva Rodrigues; Tânia Ueda-Nakamura; Arlene Gonçalves Corrêa; Diego Pereira Sangi; Celso Vataru Nakamura
Journal:  PLoS One       Date:  2014-01-17       Impact factor: 3.240

10.  Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment.

Authors:  Elena Aguilera; Javier Varela; Elva Serna; Susana Torres; Gloria Yaluff; Ninfa Vera de Bilbao; Hugo Cerecetto; Guzmán Alvarez; Mercedes González
Journal:  Mem Inst Oswaldo Cruz       Date:  2018-03       Impact factor: 2.743
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