| Literature DB >> 21034826 |
Alina C Boesteanu1, Nadarajan S Babu, Margaret Wheatley, Elisabeth S Papazoglou, Peter D Katsikis.
Abstract
Current influenza virus vaccines primarily elicit antibodies and can be rendered ineffective by antigenic drift and shift. Vaccines that elicit CD8+ T cell responses targeting less variable proteins may function as universal vaccines that have broad reactivity against different influenza virus strains. To generate such a universal vaccine, we encapsulated live influenza virus in a biopolymer and delivered it to mice subcutaneously. This vaccine was safe, induced potent CD8+ T cell immunity and protected mice against heterosubtypic lethal challenge. Safety of subcutaneous (SQ) vaccination was tested in Rag-/-γc-/- double knockout mice which we show cannot control intranasal infection. Biopolymer encapsulation of live influenza virus could be used to develop universal CD8+ T cell vaccines against heterosubtypic and pandemic strains.Entities:
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Year: 2010 PMID： 21034826 PMCID： PMC3004745 DOI： 10.1016/j.vaccine.2010.10.036
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641