| Literature DB >> 21034743 |
Radosław Polański1, Hazel E Warburton, Arpita Ray-Sinha, Timothy Devling, Hubert Pakula, Carlos P Rubbi, Nikolina Vlatković, Mark T Boyd.
Abstract
Recent studies connect MDM2 with increased cell motility, invasion and/or metastasis proposing an MDM2-mediated ubiquitylation-dependent mechanism. Interestingly, in renal cell carcinoma (RCC) p53/MDM2 co-expression is associated with reduced survival which is independently linked with metastasis. We therefore investigated whether expression of p53 and/or MDM2 promotes aggressive cell phenotypes. Our data demonstrate that MDM2 promotes increased motility and invasiveness in RCC cells (N.B. similar results are obtained in non-RCC cells). This study shows for the first time both that endogenous MDM2 significantly contributes to cell motility and that this does not depend upon the MDM2 RING-finger, i.e. is independent of ubiquitylation (and NEDDylation). Our data suggest that protein-protein interactions provide a likely mechanistic basis for MDM2-promoted motility which may constitute future therapeutic targets.Entities:
Mesh：
Substances：
Year: 2010 PMID： 21034743 DOI： 10.1016/j.febslet.2010.10.049
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124