Xue-feng Xu1, Li-zhong Du. 1. Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Abstract
OBJECTIVE: To review the role of epigenetic regulation in neonatal diseases and better understand Barker's "fetal origins of adult disease hypothesis". DATA SOURCES: The data cited in this review were mainly obtained from the articles published in Medline/PubMed between January 1953 and December 2009. STUDY SELECTION: Articles associated with epigenetics and neonatal diseases were selected. RESULTS: There is a wealth of epidemiological evidence that lower birth weight is strongly correlated with an increased risk of adult diseases, such as type 2 diabetes mellitus, hypertension, and cardiovascular disease. This phenomenon of fetal origins of adult disease is strongly associated with fetal insults to epigenetic modifications of genes. A potential role of epigenetic modifications in congenital disorders, transient neonatal diabetes mellitus (TNDM), intrauterine growth retardation (IUGR), and persistent pulmonary hypertension of the newborn (PPHN) have been studied. CONCLUSIONS: Acknowledgment of the role of these epigenetic modifications in neonatal diseases would be conducive to better understanding the pathogenesis of these diseases, and provide new insight for improved treatment and prevention of later adult diseases.
OBJECTIVE: To review the role of epigenetic regulation in neonatal diseases and better understand Barker's "fetal origins of adult disease hypothesis". DATA SOURCES: The data cited in this review were mainly obtained from the articles published in Medline/PubMed between January 1953 and December 2009. STUDY SELECTION: Articles associated with epigenetics and neonatal diseases were selected. RESULTS: There is a wealth of epidemiological evidence that lower birth weight is strongly correlated with an increased risk of adult diseases, such as type 2 diabetes mellitus, hypertension, and cardiovascular disease. This phenomenon of fetal origins of adult disease is strongly associated with fetal insults to epigenetic modifications of genes. A potential role of epigenetic modifications in congenital disorders, transient neonatal diabetes mellitus (TNDM), intrauterine growth retardation (IUGR), and persistent pulmonary hypertension of the newborn (PPHN) have been studied. CONCLUSIONS: Acknowledgment of the role of these epigenetic modifications in neonatal diseases would be conducive to better understanding the pathogenesis of these diseases, and provide new insight for improved treatment and prevention of later adult diseases.