Fang Dong1, Xiao-qin Ha. 1. Medical Experiment Center, Lanzhou Military Command General Hospital of the People's Liberation Army; Key Laboratory of Stem Cell and Gene Medicine of Gansu Province, Lanzhou, Gansu 730050, China.
Abstract
OBJECTIVE: To review the effect of endothelial progenitor cells in neovascularization as well as their application to the therapy of tumors. DATA SOURCES: The data used in this review were mainly from PubMed for relevant English language articles published from 1997 to 2009. The search term was "endothelial progenitor cells". STUDY SELECTION: Articles regarding the role of endothelial progenitor cells in neovascularization and their application to the therapy of tumors were selected. RESULTS: Endothelial progenitor cells isolated from bone marrow, umbilical cord blood and peripheral blood can proliferate, mobilize and differentiate into mature endothelial cells. Experiments suggest endothelial progenitor cells take part in forming the tumor vascular through a variety of mechanisms related to vascular endothelial growth factor, matrix metalloproteinases, chemokine stromal cell-derived factor 1 and its receptor C-X-C receptor-4, erythropoietin, Notch signal pathway and so on. Evidence demonstrates that the number and function change of endothelial progenitor cells in peripheral blood can be used as a biomarker of the response of cancer patients to anti-tumor therapy and predict the prognosis and recurrence. In addition, irradiation temporarily increased endothelial cells number and decreased the endothelial progenitor cell counts in animal models. Meanwhile, in preclinical experiments, therapeutic gene-modified endothelial progenitor cells have been approved to attenuate tumor growth and offer a novel strategy for cell therapy and gene therapy of cancer. CONCLUSIONS: Endothelial progenitor cells play a particular role in neovascularization and have attractively potential prognostic and therapeutic applications to malignant tumors. However, a series of problems, such as the definitive biomarkers of endothelial progenitor cells, their interrelationship with radiotherapy and their application in cell therapy and gene therapy of tumors, need further investigation.
OBJECTIVE: To review the effect of endothelial progenitor cells in neovascularization as well as their application to the therapy of tumors. DATA SOURCES: The data used in this review were mainly from PubMed for relevant English language articles published from 1997 to 2009. The search term was "endothelial progenitor cells". STUDY SELECTION: Articles regarding the role of endothelial progenitor cells in neovascularization and their application to the therapy of tumors were selected. RESULTS: Endothelial progenitor cells isolated from bone marrow, umbilical cord blood and peripheral blood can proliferate, mobilize and differentiate into mature endothelial cells. Experiments suggest endothelial progenitor cells take part in forming the tumor vascular through a variety of mechanisms related to vascular endothelial growth factor, matrix metalloproteinases, chemokine stromal cell-derived factor 1 and its receptor C-X-C receptor-4, erythropoietin, Notch signal pathway and so on. Evidence demonstrates that the number and function change of endothelial progenitor cells in peripheral blood can be used as a biomarker of the response of cancerpatients to anti-tumor therapy and predict the prognosis and recurrence. In addition, irradiation temporarily increased endothelial cells number and decreased the endothelial progenitor cell counts in animal models. Meanwhile, in preclinical experiments, therapeutic gene-modified endothelial progenitor cells have been approved to attenuate tumor growth and offer a novel strategy for cell therapy and gene therapy of cancer. CONCLUSIONS: Endothelial progenitor cells play a particular role in neovascularization and have attractively potential prognostic and therapeutic applications to malignant tumors. However, a series of problems, such as the definitive biomarkers of endothelial progenitor cells, their interrelationship with radiotherapy and their application in cell therapy and gene therapy of tumors, need further investigation.
Authors: Shilpi Rajoria; Robert Suriano; Yushan L Wilson; Andrea L George; Jan Geliebter; Stimson P Schantz; Raj K Tiwari Journal: Oncol Lett Date: 2011-03-21 Impact factor: 2.967
Authors: Shilpi Rajoria; Robert Suriano; Andrea L George; Ameet Kamat; Stimson P Schantz; Jan Geliebter; Raj K Tiwari Journal: J Transl Med Date: 2012-05-01 Impact factor: 5.531