Literature DB >> 21030880

The feasibility of plerixafor as a second-line stem cell mobilizing agent in children.

Kanakkande Aabideen1, Parameswaran Anoop, Mark E Ethell, Mike N Potter.   

Abstract

In patients heavily pretreated with myelosuppressive chemotherapy or irradiation, Granulocyte colony stimulating factor (G-CSF) may fail to mobilize stem cells from the bone marrow. Plerixafor is emerging as a reliable alternate option in such situations in adult patients. Robust data in support of the high efficacy and safety of plerixafor are available in adults. Very little evidence is available on the usefulness of this drug among children. We report our experience with plerixafor usage on 5 occasions in pediatric patients, with a success rate of 60%. No significant side effects were encountered in any patient.

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Year:  2011        PMID： 21030880     DOI： 10.1097/MPH.0b013e3181e9e4c2

Source DB:  PubMed          Journal:  J Pediatr Hematol Oncol        ISSN： 1077-4114            Impact factor:   1.289


  5 in total

Review 1.  Successful mobilisation of peripheral blood stem cells in children using plerixafor: a case report and review of the literature.

Authors:  Angelo Gardellini; Aleksandra Babic; Federica Gigli; Sarah Jane Liptrott; Giovanni Martinelli; Daniele Laszlo
Journal:  Blood Transfus       Date:  2012-10-10       Impact factor: 3.443

Review 2.  Plerixafor: a review of its use in stem-cell mobilization in patients with lymphoma or multiple myeloma.

Authors:  Gillian M Keating
Journal:  Drugs       Date:  2011-08-20       Impact factor: 9.546

3.  Efficacy of plerixafor in children with malignant tumors failing to mobilize a sufficient number of hematopoietic progenitors with G-CSF.

Authors:  A A Maschan; D N Balashov; E E Kurnikova; P E Trakhtman; E V Boyakova; E V Skorobogatova; G A Novichkova; M A Maschan
Journal:  Bone Marrow Transplant       Date:  2015-04-27       Impact factor: 5.483

4.  Successful mobilization using a combination of plerixafor and G-CSF in pediatric patients who failed previous chemomobilization with G-CSF alone and possible complications of the treatment.

Authors:  Kyung Taek Hong; Hyoung Jin Kang; Nam Hee Kim; Min Sun Kim; Ji Won Lee; Hyery Kim; Kyung Duk Park; Hee Young Shin; Hyo Seop Ahn
Journal:  J Hematol Oncol       Date:  2012-03-30       Impact factor: 17.388

5.  Plerixafor stem cell mobilization in Japanese children: A post-marketing study.

Authors:  Hiroaki Goto; Rie Kanamori; Satoshi Nishina; Takashi Seto
Journal:  Pediatr Int       Date:  2022-01       Impact factor: 1.617
  5 in total

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