BACKGROUND: Some patients who are initially diagnosed with ductal carcinoma in situ (DCIS) by core biopsy eventually have their disease upstaged to invasive carcinoma on final excision, thus warranting some form of axillary staging. This study aimed to identify the predictors of invasive breast cancer in DCIS diagnosed by core biopsy, which could then help clinicians decide which cases of biopsy-diagnosed DCIS should undergo concurrent sentinel lymph node biopsy during excision. METHODS: The records of 95 consecutive patients diagnosed with pure DCIS from 100 core biopsies from January 2005 to August 2007 were retrospectively reviewed. The clinical, radiological and pathological characteristics of these 100 cases were correlated with the presence of invasion or microinvasion on excision. RESULTS: Factors that are associated with invasive or microinvasive foci on excisional histology are: size of target lesion on radiography ≥ 20 mm [odds ratio: 6.738 (1.050-43.236), p = 0.044] and ≤ 10 cores obtained [odds ratio: 22.343 (2.351-212.385), p = 0.007]. CONCLUSION: Underestimation of invasive breast cancer in core biopsy-diagnosed DCIS is related to the size of the lesion on radiography, as well as the number of cores obtained during biopsy.
BACKGROUND: Some patients who are initially diagnosed with ductal carcinoma in situ (DCIS) by core biopsy eventually have their disease upstaged to invasive carcinoma on final excision, thus warranting some form of axillary staging. This study aimed to identify the predictors of invasive breast cancer in DCIS diagnosed by core biopsy, which could then help clinicians decide which cases of biopsy-diagnosed DCIS should undergo concurrent sentinel lymph node biopsy during excision. METHODS: The records of 95 consecutive patients diagnosed with pure DCIS from 100 core biopsies from January 2005 to August 2007 were retrospectively reviewed. The clinical, radiological and pathological characteristics of these 100 cases were correlated with the presence of invasion or microinvasion on excision. RESULTS: Factors that are associated with invasive or microinvasive foci on excisional histology are: size of target lesion on radiography ≥ 20 mm [odds ratio: 6.738 (1.050-43.236), p = 0.044] and ≤ 10 cores obtained [odds ratio: 22.343 (2.351-212.385), p = 0.007]. CONCLUSION: Underestimation of invasive breast cancer in core biopsy-diagnosed DCIS is related to the size of the lesion on radiography, as well as the number of cores obtained during biopsy.
Authors: Rui Hou; Lars J Grimm; Maciej A Mazurowski; Jeffrey R Marks; Lorraine M King; Carlo C Maley; Thomas Lynch; Marja van Oirsouw; Keith Rogers; Nicholas Stone; Matthew Wallis; Jonas Teuwen; Jelle Wesseling; E Shelley Hwang; Joseph Y Lo Journal: Radiology Date: 2022-01-04 Impact factor: 29.146
Authors: Suzanne C E Diepstraten; Stephanie M W Y van de Ven; Ruud M Pijnappel; Petra H M Peeters; Maurice A A J van den Bosch; Helena M Verkooijen; Sjoerd G Elias Journal: PLoS One Date: 2013-10-11 Impact factor: 3.240
Authors: Ern Yu Tan; Z W Joseph Lo; Chuan Han Ang; Christine Teo; Melanie D W Seah; Juliana J C Chen; Patrick M Y Chan Journal: Int Sch Res Notices Date: 2014-10-29
Authors: Kwan Ho Lee; Jeong Woo Han; Eun Young Kim; Ji Sup Yun; Yong Lai Park; Chan Heun Park Journal: BMC Cancer Date: 2019-12-10 Impact factor: 4.430